Quantifying flow of information in a program involves calculating how much information (e.g. about secret inputs) can be leaked by observing the program’s public outputs. Recently this field has attracted a lot of research interest, most of which makes use of Shannon’s information theory, e.g. mutual information, conditional entropy, etc. Computability entails that any automated analysis of inf...

In this research, we investigate a three-stage supply chain with one supplier, several manufacturers and multiple retailers where the supplier provides a common raw material to each manufacturer, who in turn uses a single stage production facility to convert it into final products that are delivered at fixed lot sizes to retailers. An integrated economic procurement, production, and delivery mo...

Surface layer as the outer protective coverage of bacteria and archaea are two-dimensional crystalline and symmetrical arrays of proteins that recently attract a lot of attention for biologist scientists. The surface layers of bacteria are usually 5 to 10 nm in diameter and represent highly porous protein lattices with uniform size and morphology with the pore sizes of 2 to 8 nm. The crucial an...

AIM To develop a decisional tool to identify the most cost effective process flowsheets for allogeneic cell therapies across a range of production scales. MATERIALS & METHODS A bioprocess economics and optimization tool was built to assess competing cell expansion and downstream processing (DSP) technologies. RESULTS Tangential flow filtration was generally more cost-effective for the lower...