results trail making test part b cognitive test showed statistically significant in comparison for pre and post exposure of anesthetics. this difference was seen in the desflurane group. other cognitive tests did not show differences on exposure to the anesthetic gases. conclusions this study questioned the difference between volatile anesthetic agent’s effects on patients completing a battery ...

Multiple sclerosis (MS) is a progressive demyelinating disease presenting with a relapsing-remitting course and affects large areas of the brain and the spinal cord. Surgical stress often induces exacerbation of MS symptoms. It is mandatory to prepare the MS patient very carefully for the surgery and anaesthesia with an effective premedication and an effective postoperative analgesia following ...

Mustafa Yontem*1, Aydın Akkaya2, Suleyman Kaleli3, Fatih Erci1, Fatma Emel Kocak4 1Necmettin Erbakan University, Faculty of Science, Department of Biotechnology, Konya, Turkey 2Dumlupinar University, Faculty of Science, Department of Biology, Kutahya, Turkey 3Sakarya University, Faculty of Medicine, Department of Medical Biology, Sakarya, Turkey 4Dumlupınar University, Faculty of Medicine, Depa...

Background: The fifth largest contributors of greenhouse gases (GHGs) worldwide are healthcare systems.1 In 2015, the National Health Service (NHS) contributed ∼4.6% national GHGs.2 NHS sustainable team has labelled anaesthetic volatile (GHG) as a ‘carbon hotspot’.3 Long Term Plan is to reduce 40% emissions from agents.4 global warming potential (GWP100) desflurane almost 20 times more than tha...

BACKGROUND Inhibition of voltage-gated Na channels (Na(v)) is implicated in the synaptic actions of volatile anesthetics. We studied the effects of the major halogenated inhaled anesthetics (halothane, isoflurane, sevoflurane, enflurane, and desflurane) on Na(v)1.4, a well-characterized pharmacological model for Na(v) effects. METHODS Na currents (I(Na)) from rat Na(v)1.4 alpha-subunits heter...