OBJECTIVES To estimate the prevalence and predictors of interstitial lung disease in newly diagnosed polymyositis and dermatomyositis. METHODS A prospective study in which consecutive patients with newly diagnosed poly- and dermatomyositis, regardless of clinical symptoms of pulmonary disease, were investigated with chest x ray, high resolution computed tomography (HRCT), pulmonary function t...

(nodular sclerosis). Further investigations established that his tumour was stage II A. Accordingly, methotrexate was discontinued and a full course of radiation therapy delivered immediately. After six months of follow up the patient had no evidence of disease relapse. The table summarises nine reported patients2" who developed malignancies while receiving methotrexate therapy. Patient 74 show...

BACKGROUND The pathogenesis of the inflammatory processes in the skin of dermatomyositis patients remains unclear. The aim of this study was to investigate the patterns of proliferation and apoptosis of epidermal keratinocytes and dermal infiltrating cells in DM patients. MATERIAL AND METHODS Seventeen skin biopsy specimens from patients with dermatomyositis, which fulfilled the diagnostic cr...

(nodular sclerosis). Further investigations established that his tumour was stage II A. Accordingly, methotrexate was discontinued and a full course of radiation therapy delivered immediately. After six months of follow up the patient had no evidence of disease relapse. The table summarises nine reported patients2" who developed malignancies while receiving methotrexate therapy. Patient 74 show...

Polymyositis, dermatomyositis, and inclusion body myositis, although immunopathologically distinct, share 3 dominant histological features: inflammation, fibrosis, and loss of muscle fibers. Progress in molecular immunology and immunogenetics has enhanced our understanding of these cellular processes. Based on the T-cell receptor gene rearrangement, the autoinvasive CD8+ T cells in polymyositis...

INTRODUCTION Dermatomyositis has been described in the setting of lyme infection in only nine previous case reports. Although lyme disease is known to induce typical clinical findings that are observed in various collagen vascular diseases, to our knowledge, we believe that our case is the first presentation of acute lyme disease associated with amyopathic dermatomyositis, which was then follow...

INTRODUCTION Dermatomyositis is a chronic inflammatory disorder characterized by muscular and dermatologic symptoms with variable internal organ involvement. This is the first report on a patient with acute dermatomyositis and fulminant systemic capillary leak syndrome. CASE PRESENTATION A 69-year-old Caucasian woman with chronic dermatomyositis presented with clinical signs of severe hypovol...

<p class="abstract">Juvenile dermatomyositis (JDM) is a rare autoimmune disease that affects mostly children's muscles and skin. The small number of patients with JDM, heterogeneous phenotype, few clinical trials for JDM pose challenges clinicians in developing standard treatment protocols. Although there has been some consensus, the obstacles to therapy, especially refractory cases, have...

Genome-wide association study in collies identifies a novel locus for dermatomyositis"