Anti-malarial drugs may induce numerous cutaneous adverse drug reactions as well as exacerbation of psoriasis. Acute generalized exanthematous pustulosis (AGEP) is a clinical reaction pattern that is principally drug induced and is characterized by acute, extensive formation of non-follicular sterile pustules on an erythematous and oedematous substrate. Hydroxychloroquine (HCQ), an anti-malaria...

We report a case of spontaneous familial pneumothorax in fraternal twin boys. The twins' family history is remarkable for reactive airway disease and a female sibling also born with spontaneous pneumothorax. The family had no history of connective tissue disorders, renal cancer, or dermatologic diseases. Analysis of the twins' α(1)-antitrypsin (AAT) genotype, phenotype, and serum concentration ...

Exposure to chemical carcinogens in rubber manufacturing remains a serious occupational health concern. Workers are exposed to these carcinogens via skin or inhalation. Rubber manufacturing work is associated with a high prevalence of dermatologic diseases such as eczema, allergic contact dermatitis and atopic dermatitis. The role that epidermal exposure plays in the development of malignancies...

Cosmetic surgeons are often asked to evaluate and treat a host of different dermatologic diseases. Some conditions may fall outside the realm of what they see daily in their practice, as they are not very common. We were recently presented with a patient with rhinophyma, which is considered the most severe expression of acne rosacea. In its severe form, rhinophyma is quite disÞ guring and can l...

CLINICAL CHALLENGE Patients are not always forthcoming about their tobacco use. Smoking and other forms of tobacco use have serious health consequences, and many dermatologic diseases and treatments are negatively affected by tobacco exposure. When a patient does not disclose their full tobacco history, the dermatologist can miss a valuable opportunity to counsel the patient on tobacco cessatio...

BP: bullous pemphigoid DP: dyshidrosiform pemphigoid INTRODUCTION Dyshidrosiform bullous pemphigoid (DP) is an unusual localized variant of bullous pemphigoid (BP), first described by Levine et al in 1979. It presents with a persistent and recurrent vesicobullous eruption, sometimes hemorrhagic, localized to the soles and/or palms. Since the clinical manifestations of DP are similar to those of...

Patients with hyperandrogenic syndromes and diseases exacerbated by pregnancy and those taking common dermatologic drugs associated with risk to the fetus require prescription of contraceptives by the dermatologist. In healthy, nonsmoking women, oral contraception does not increase the risk of cerebral or cardiac vascular disease and is associated with major benefits besides avoiding pregnancy....