In the generally accepted schemes for the biosynthesis of adrenal cortical steroids (l-3), progesterone* is represented as the branch point in the formation of 17-hydroxycorticosteroids (Reactions D and F, Fig. l), on the one hand, and the 17-deoxycorticosteroids (Reaction E, Fig. l), on the other. Savard et al. (4) found that incubation of slices of an interstitial cell tumor of the testis wit...

The adverse outcomes seen in the Women's Health Initiative (WHI) 1 were mainly due to an over-dosage of hormones in a relatively elderly population. However, fundamental differences exist between conjugated equine estrogens and 17 beta estradiol and between medroxyprogesterone acetate and natural progesterone. It is likely that these differences also contributed to the adverse outcomes in WHI, ...

Sex steroid hormone progesterone is known to have profound effects on the growth and differentiation of the normal mammary gland and malignant breast epithelial cells. In vitro progesterone and synthetic progesterone-like compounds (progestins) inhibit breast cancer cell growth. Medroxyprogesterone acetate (MPA) is a synthetic hormone widely used in the adjuvant treatment of advanced breast can...

INTRODUCTION In the U.S., it is estimated that onehalf of the six million pregnancies that occur each year are unplanned or un expected.1 Despite the widespread of use of various contraceptive methods, including hormonal contraceptive tablets and condoms, these methods remain imperfect. Inadequate contraceptive use or failure of a contraceptive method, in addition to unprotected sexual intercou...

1. The effect of progesterone on renal haemodynamics and intrarenal sodium handing was evaluated in thirteen normal men on a constant diet. Clearances were measured during maximal water diuresis and again 4-7 days later, this time 3 h after progesterone was given intramuscularly. Seven additional studies were performed 3 days after progesterone administration. Another four tests were performed ...

OBJECTIVE To identify continuation rates of depot medroxyprogesterone acetate (Depo-Provera) and characteristics of long-term users in a population of inner-city, minority adolescents with high pregnancy rates. DESIGN Retrospective medical record review. SETTING An inner-city adolescent clinic and an adolescent pregnancy program. METHODS A review of the medical records of 250 females aged...

A total number of 28 mature Barki ewes were divided into three groups according to the methods used for synchronization of estrous cycle with different drugs. Group I comprised 8 ewes received no drugs and served as control group. Group II included 10 ewes synchronized by 3 ml (15 mg) prostaglandin F2  injected i.m and repeated once after 9 days from the first injection.Group III comprised 10 ...

BACKGROUND The effects of progestogens on endothelial physiology are poorly studied. Prostacyclin is a potent vasodilator synthesized by two isoforms of cyclooxygenase (COX) in endothelium. We examined the effects of two clinically used progestogens, progesterone and medroxyprogesterone acetate (MPA), on prostacyclin production by cultured human umbilical vein endothelial cells (HUVEC) and the ...

Understanding preference of source of contraceptive commodities is essential in enhancing the delivery of family planning services. This paper identifies the determinants of preferred source of Depo-Provera among rural women in Uganda. The analysis is based on data sourced from a Save the Children and Family Health International study involving 642 women who were introduced to the contraceptive...