We evaluate an approach to detect single-nucleotide polymorphisms (SNPs) that account for a linkage signal with covariate-based affected relative pair linkage analysis in a conditional-logistic model framework using all 200 replicates of the Genetic Analysis Workshop 17 family data set. We begin by combining the multiple known covariate values into a single variable, a propensity score. We also...

We describe a design for cancer phase I clinical trials that takes into account patients heterogeneity thought to be related to treatment susceptibility. The goal is to estimate the maximum tolerated dose MTD given patient’s specific dichotomous covariate value. The design is Bayesian adaptive and is an extension of escalation with overdose control EWOC . We will assess the performance of this ...

A phenomenon often found in session-to-session transfers of brain-computer interfaces (BCIs) is nonstationarity. It can be caused by fatigue and changing attention level of the user, differing electrode placements, varying impedances, among other reasons. Covariate shift adaptation is an effective method that can adapt to the testing sessions without the need for labeling the testing session da...

Meta-analyses that synthesize statistical evidence across studies have become important analytical tools for genetic studies. Inspired by the success of genome-wide association studies of the genetic main effect, researchers are searching for gene × environment interactions. Confounders are routinely included in the genome-wide gene × environment interaction analysis as covariates; however, thi...

Cet article traite de l’estimation en présence covariables fonctionnelles. Plus précisément, nous souhaitons estimer une fonction régression m entre variable réponse réelle Y et un coprocessus Wiener standard W. En inspirant Cadre Truquet (ESAIM Probab. Stat. 19 (2015) 251–267) al. 21 (2017) 138–158), utilisons la décomposition Wiener–Itô m(W) afin construire famille d’estimateurs. Nous obtenon...

BACKGROUND Many medical procedures routinely use body weight as a parameter for calculation. However, these measurements are not always available. In addition, the commonly used visual estimation has had high error rates. Therefore, the aim of this study was to develop a predictive equation for body weight using body circumferences. METHODS A prospective study was performed in healthy volunte...

The comparison of Receiver Operating Characteristic (ROC) curves is frequently used in the literature to compare discriminatory capability different classification procedures based on diagnostic variables. performance these variables can be sometimes influenced by presence other covariates, and thus they should taken into account when making comparison. A new non-parametric test proposed here f...

The Cox proportional hazards (PH) model with time-dependent covariates (referred to as the extended PH model) has been widely used in medical and health related studies to investigate the effects of time-varying risk factors on survival. Theories and practices regarding model estimation and fitting have been well developed for the extended PH model. However, little has been done regarding sampl...

Background: Poisoning is a medical emergency, and considered as common cause of morbidity mortality worldwide. In this study, the extended Cox model was used to determine factors affecting length hospitalization in those with drug poisoning. Methods: The sample size included 2408 patients opioids poisoning referring Emergency Department Imam Reza Hospital Mashhad, Iran from March 21, 2018 20, 2...