Human dental pulp stem cells (DPSCs), unique mesenchymal stem cells (MSCs) type, exhibit the characteristics of self-renewal and multi-lineage differentiation capacity. Oct4 and Nanog are pluripotent genes. The aim of this study was to determine the physiological functions of Oct4 and Nanog expression in DPSCs. Herein, we determined the critical role of an Oct4/Nanog axis modulating MSCs proper...

Within the field of tissue engineering, natural tissues are reconstructed by combining growth factors, stem cells, and different biomaterials to serve as a scaffold for novel tissue growth. As adequate vascularization and innervation are essential components for the viability of regenerated tissues, there is a high need for easily accessible stem cells that are capable of supporting these funct...

The aim of regenerative medicine is to restore the original functions tissues and organs damaged by disease or impairment. Stem cell transfusion has been used clinically as therapy in a wide range fields. This promotes regeneration partially transfer tissue stem cells. Teeth are produced from dental germ, which induced interactions between epithelial mesenchymal Wnt signals heavily involved thi...

Dental pulp stem cells (DPSCs) secrete neurotrophic factors which may play an important therapeutic role in neural development, maintenance and repair. To test this hypothesis, DPSCs-conditioned medium (DPSCs-CM) was collected from 72 hours serum-free DPSCs cultures. The impact of DPSCs-derived on PC12 survival, growth, migration differentiation investigated. were treated with nerve growth fact...

Background  Wisdom teeth are usually removed as a routine procedure for therapeutic or prophylactic reasons. Developing wisdom teeth are easy accessible source of stem cells during the adulthood which could be obtained. Methods  Search of the PubMed for stem cells and tooth was done. An inclusion criterion was extract of stem cells from wisdom tooth. Results  Stem cells can be obtained fro...

NUMB is a multifunctional protein implicated to function in self-renewal and differentiation of progenitors in several tissues. To characterize the transcripts and to analyze the expression pattern of NUMB in odontogenesis, we isolated 2 full-length clones for NUMB from mouse dental pulp mRNA. One novel sequence contained 200 bp insertion in the phosphotyrosine binding domain (PTB). Confocal mi...

In medicine stem cell-based treatments are being used in conditions like Parkinson's disease, neural degeneration following brain injury, cardiovascular diseases, diabetes, and autoimmune diseases. In dentistry, recent exciting discoveries have isolated dental stem cells from the pulp of the deciduous and permanent teeth, from the periodontal ligament, and an associated healthy tooth structure,...

Stem Cell Research is the most fascinating area of biology today. The discovery of stem cells dates back to 1950’s when various experiments with bone marrow established their identity and their powerful role in regeneration of lost tissues. In the medical field scientists that stem cells offer a viable source of replacement cells to treat diseases like Diabetes, Parkinson’s disease and cardiova...

AIM To examine the effect of inflammatory stimuli on the proliferation/migration of dental pulp stem cells by assessing the responses of stem cell-associated marker-expressing cells in rat incisors to lipopolysaccharide (LPS) stimulation in vivo. METHODOLOGY The crowns of rat incisors were removed, and the coronal pulp chamber was instrumented. After haemostasis, an absorbent point soaked in ...