Familial Hypercholesterolemia (FH) is a genetic disorder, an expression of defect in the gene that responsible for production LDL-C receptor. The current study was designed to determine FH patients city Sulaymaniyah both sexes. included 213 samples, number males 99 and females 114, sexes ranged from (30-79) years.The results cholesterol, triglyceride, high density lipoprotein (HDL-C), low-densi...

In view of the presence of some 190 mutations in the low density lipoprotein receptor (LDL-R) gene and a lack of simple detection methods, we have developed an improved assay system for detecting familial hypercholesterolemia (FH) using mitogen-induced proliferating lymphocytes. Freshly isolated mononuclear cells were cultured for 3 days in RPMI 1640 supplemented with 10% human lipoprotein-defi...

Methods Patients treated with LPV with undetectable viral load since 6 months were switched to ATZ or DRV if they have low density lipoprotein (LDL)>1.6 g/l with no other cardiovascular risk, LDL>1.3g/l with at least 1 cardiovascular risk, or high density lipoprotein (HDL) <0.35mmo/l. None of the patients had an additional lipid-lowering treatment since 3 months, and others antiretroviral treat...

Background/aim: Juvenile obesity is associated with several metabolic abnormalities, one of them being atherogenic dyslipidemia. Suboptimal fetal growth is associated with obesity risk in childhood, but also with increased rate of metabolic diseases in later life. This study investigated associations of neonatal data (Apgar score, birth weight and birth length) with low-density lipoprotein and ...

High-density lipoprotein (HDL) has been proposed as the principal carrier of hydroperoxides in plasma, based upon data gathered with an HPLC-chemiluminescence technique. To test this hypothesis we have measured total lipid hydroperoxides in native plasma using the ferrous oxidation in Xylenol Orange (FOX) assay and then fractionated plasma into very-low-density lipoprotein (LDL) and HDL fractio...

AIM Nutritional parameters, such as B-vitamins, have not been studied for an association with low-density lipoprotein (LDL) particle size. The present study explored whether serum vitamin levels, including folate and vitamin B-12, could be associated with LDL particle size. METHODS Using a randomly selected population of 255 hospital workers, we collected detailed lipid profiles, including tr...

The objective of the present study was to establish whether high-density lipoprotein 3 (HDL3) or high-density lipoprotein 2 (HDL2) might show an anti-oxidative effect on the acceleration of the oxidative modification of low-density lipoprotein (LDL) by ascorbic acid from measurement of the agarose gel electrophoretic mobility of LDL. LDL was incubated without adding transitional-metal ions for ...

We evaluated the influence of the levels of glycosylated hemoglobin (HbA1C) and fasting plasma glucose on the variation in low density lipoprotein (LDL) peak particle size in 210 subjects who were undergoing an annual check-up. Univariate analysis showed that LDL particle size was significantly and positively correlated with high density lipoprotein (HDL) cholesterol levels, and was inversely c...

background: some coincidental disorders with migraine have been introduced that may have role in its pathogenesis or aggravation. in this study we determined the relative frequency of hyperlipidemia as a coincidental disorder in patients affected by migraine. methods: a total of 102 migraine-affected patients according to international headache society (his) criteria and 103 control subjects ad...

BACKGROUND Changes in conventional lipid risk factors with gemfibrozil treatment only partially explain the reductions in coronary heart disease (CHD) events experienced by men in the Veterans Affairs High-Density Lipoprotein Intervention Trial (VA-HIT). We examined whether measurement of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle subclasses provides additional in...