Red blood cell (RBC) alloimmunization may occur following transfusion or pregnancy/delivery. Although observational human studies have described the immunogenicity of RBC antigens and the clinical significance of RBC alloantibodies, studies of factors influencing RBC alloimmunization in humans are inherently limited by the large number of independent variables involved. This manuscript reviews ...

We previously showed that the covalent modification of the red blood cell (RBC) surface with methoxypoly(ethylene glycol) [mPEG; MW D5 kD] could significantly attenuate the immunologic recognition of surface antigens. However, to make these antigenically silent RBC a clinically viable option, the mPEG-modified RBC must maintain normal cellular structure and functions. To this end, mPEG-derivati...

We reported previously that spline interpolation is effective as a pretreatment before analyzing clinical data by time series. However, further improvement is required to understand the detailed tendency of clinical data. In this study, the tendency of interpolated hematological data was investigated in the period between the most tolerated dose (MTD) and low-dose chemotherapy (LDC) for colorec...

Experimental observations show that a strong magnetic field has a dramatic influence on the sedimentation of RBCs, which motivates us to model the sedimentation of red blood cell (RBC) under strong external magnetic body force. To model the sedimentation of a RBC in a square duct and a circular pipe, a recently developed technique derived from the lattice Boltzmann and the distributed Lagrange ...

BACKGROUND Smoking is a leading cause of premature death. Red blood cell (RBC) membrane lipids are rich in polyunsaturated fatty acids; therefore, the effect of oxygen on RBC membranes is more prominent than on other body tissues. The attachment of peroxidants to RBC membranes can result in hemolysis. OBJECTIVES The present study was conducted to assess the sensitivity of RBCs to 2,2'-azo-bis...

Dear Sir, Red blood cell (RBC) alloimmunisation is a delayed adverse transfusion reaction whose rate has been evaluated in women in comparison to men in various studies. In their review, Verduin et al.1 showed that women with sickle cell disease were at a higher relative risk (27.0%) of developing RBC alloimmunisation compared to men with the same disease. In the other groups of patients, the r...

Human red blood cells (RBCs) are normally phagocytized by macrophages of splenic and hepatic sinusoids at 120 days of age. The destruction of RBCs is ultimately controlled by antagonist effects of phosphatidylserine (PS) and CD47 on the phagocytic activity of macrophages. In this work, we introduce a conceptual model that explains RBC lifespan as a consequence of the dynamics of these molecules...

In the past two decades, under the conditions that both the osmotic pressure ∆p and tensile stress λ equal zero, a rigorous solution (RS) of human red blood cell (RBC) with a minus spontaneous curvature c0 has been derived with Helfrich model. And, by fitting with observed shapes of RBC, c0R0 has been predicted to be -1.62 as minus golden ratio, where R0 is the radius of a sphere with the same ...

BACKGROUND Desferrioxamine (DFO) is an important iron chelating agent. It has also been thought of as an agent with anti-oxidant potential as it chelates ferric iron in various parts of the body. However, there is evidence suggesting that it may paradoxically affect red blood cells (RBC) by inducing intracellular oxidant stress. To further understand the mechanism of DFO's interaction with RBC,...

BACKGROUND Burn-denatured dermis is able to regain the function and shape of normal dermis; however, the potential mechanisms are still vague. The aim of this study was to investigate roles of miR-100 involved in the growth and migration of burn-denatured fibroblasts. MATERIAL AND METHODS Quantitative real-time polymerase chain reaction(qRT-PCR) was used to assess the expression of miR-100. Tra...