To understand the molecular mechanisms of cellular signaling of atrial natriuretic peptide (ANP), we have studied its effect on the enzymatic activity of endogenous and overexpressed protein kinase C (PKC) in rat thoracic aortic vascular smooth muscle (RTASM) cells. Angiotensin II (ANG II), endothelin-1 (ET-1), and 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulated fourfold to fivefold PKC a...

Extensive decision-making during the vaccine preparation period is unpredictable. An account of severity disease, younger people with COVID-19 comorbidities and other chronic diseases are also at a higher risk pandemic. In this research article, preference ranking structure for recommended young who have been exposed to effects certain diseases. Multiple Criteria Decision-Making (MCDM) approach...

In this paper we study the multicriteria decision aid (MCDA) methods PROMETHEE and GAIA. The PROMETHEE method provides the decision maker with a ranking. The GAIA method provides a two dimensional representation of the decision problem based on the flows computed by the PROMETHEE method. However, a limit of the GAIA method is the loss of information by its two-dimensional projection which may l...

We examined the inhibitory effect of porcine C-type natriuretic peptide (CNP) on endothelin-1 secretion stimulated by thrombin and angiotensin II (Ang II) in cultured porcine endothelial cells. The results were compared with the effects of atrial (ANP) and brain (BNP) natriuretic peptides. Thrombin and Ang II produced a concentration-dependent stimulation of immunoreactive endothelin-1 secretio...

In anesthetized rats, the renal excretory actions of atrial natriuretic peptide (ANP) are inhibited by intravenous or intraperitoneal injections of bradykinin. To elucidate the mechanisms underlying this inhibition, we evaluated bradykinin effects on: i- ANP-induced natriuresis and diuresis in isolated perfused rat kidneys, and ii- ANP-induced cGMP production in rat renal medulla in vitro. In p...

In this paper we describe the data for five real applications of multicriteria methods in the context of environmental problems. The applications are: (1) the choice of a solid waste management system for the Uusimaa region, Finland, (2) for the Jämsä region, Finland, (3) the Oulu region, Finland, (4) locating a waste treatment facility in the Savonlinna region, Finland, and (5) choosing among ...

Purpose The purpose of this study is to provide a model for evaluating, prioritizing and allocating orders suppliers in the supply chain mega-projects. Design/methodology/approach By using an integrated (based on fuzzy analytic network process), are selected appropriate amounts allocated them Initially, hierarchical research method was introduced. Then, results reliability validity analysis mea...

We examined the contractile effect of angiotensin II on isolated rat glomeruli and cultured glomerular mesangial cells, as well as the possible involvement of calcium in this contraction. In addition, the effect of rat atrial natriuretic peptide (ANP) on angiotensin II-induced contraction was studied. Computer-assisted image analysis was used to measure glomerular cross-sectional area and plana...