ethosomes are a novel and alternative drug delivery systems and currently the focus of many research activities. ethosomes are soft, flexible vesicles that are composed mainly of phospholipids, ethanol and water. ethosomes can provide better skin permeation than liposomes and deliver enhanced amounts of both small and large therapeutic agents through skin and targeting to deeper skin layers for...

objective: to clarify the principles of a safe delivery based on clinical governance criteria, as recommended by the pertinent experts. materials and methods: the current study was part of a qualitative research conducted by content analysis method in 2013 and purposive sampling, performing 24 in-depth interviews based on semi-structured questions and analyzed using thematic content analysis. t...

objective(s):the aim of this study was to prepare electrospun nanofibers of celecoxib using combination of time-dependent polymers with pectin to achieve a colon-specific drug delivery system for celecoxib. materials and methods:formulations were produced based on two multilevel 22 full factorial designs. the independent variables were the ratio of drug:time-dependent polymer (x1) and the amoun...

introduction: the risk of morbidity and mortality increases in neonates admitted to the neonatal intensive care units (nicus). various factors contribute to the prognosis of these newborns. in the current study, we aimed to investigate the role of mode of delivery on short-term neonatal outcomes. methods: this retrospective study was conducted on 215 neonates admitted to the nicu of shohada-e-t...

pain management is crucially important in the postoperative period as it increases patient comfort and satisfaction. the primary outcome of present study was to evaluate the effect of sufentanil added to hyperbaric bupivacaine solution 0.25% in transversus abdominis plane (tap) block, on postoperative analgesic consumption. fifty asa physical status i–ii term primiparous single-tone pregnant wo...

this study was designed to assess the frequency of exclusive breastfeeding in two health centers of shahid beheshti university of medical sciences in khak sefid, tehran, iran. a total of 175 mothers, referred for the third dose of their infants' dpt vaccination program participated in the study by completing a questionnaire regarding characteristics of their pregnancy, delivery and exclusive br...

the nasal cavity possesses many advantages as a site for drug delivery, such as, ease of administration, applicability for long term treatments and a large surface area for absorption. one important limiting factor for nasal drug delivery is the limited time available for absorption within the nasal cavity due to mucociliary clearance. several drug delivery systems including different kinds of ...

objective(s): nanoparticles (nps) are known for their specific accumulation in the inflamed tissues of the colon and thus allow a selective delivery to the site of inflammation with minimum adverse effects. the main objective of this work is to attain mesalamine loaded chitosan nanoparticles as a carrier for oral delivery. methods: in this study, mesalamine loaded chitosan nanoparticles were pr...

P regnancy-induced hypertension is characterized by hypertension, proteinuria, edema, and, at times, abnormalities of the coagulation system and liver function. Reduced placental blood flow is a hallmark of the condition, and by definition, the blood pressure returns to normal after delivery. It occurs in 5 to 10% of all pregnancies, primarily in primigravidas after the 20th week of gestation. ...

nowadays apphcanon of nanotubes in biology and medicinal science is more investigated. nanotubes can passthroueh cell walls and transport and release drugs in special tissues. the purpose of this paper is to investigatethe interaction of a nanotube having hydroxyl functional groups (oh) with an anticancer agent. in this worktransporting of an anticancer drug named 2-(2-amino 6,7-dimethyl pterid...