gene therapy as a modern therapeutic approach has not yet advanced to a globally-approved therapeutic approach. lack of adequate reliable gene delivery system seems to be one of the major reasons from the pharmaceutical biotechnology point of view. main obstacles delaying successful application of human gene therapy are presented in this review. the unique advantages of non-biological gene carr...

background: world health organization (who) defines three goals to assess the performance of a health system: the state of health, fairness in financial contribution and responsiveness. we assessed the responsiveness of health system for patients with diabetes in a defined population cohort in tehran, iran. methods: total responsiveness and eight domains (prompt attention, dignity, communicatio...

leptospirosis is one of the most prevalent zoonotic diseases worldwide. currently, multivalent whole-cell leptospiral vaccines can induce protection against leptospirosis. therefore, preparation and formulation of new generations of vaccines that can stimulate long-term immunity for leptospirosis control are essential. the aim of this study was to prepare and characterize alginate microspheres ...

the silver nanoparticles are well-known for their antimicrobial, anti-inflammatory wound healing abilities. we synthesized silver nanoparticles using chemical reduction method and the formation of the silver nanoparticles was characterized by uv-vis absorption spectroscopy, ft-ir and sem techniques. the minimum inhibitory concentration of the synthesized nanoparticles was determined for both gr...

background & aim: postpartum period is accompanied by significant changes in women’s quality of life. these alterations can affect the health of mothers and children. considering the importance of postnatal quality of life and its different contributing factors, this study aimed to compare women’s quality of life after vaginal delivery and cesarean section. methods:this retrospective cohort stu...

the aim of this study is to formulate a novel ophthalmic nanosuspension (ons), an alternative carrier system to traditional colloidal carriers for controlled release (cr) of acyclovir (acv). in the present study, ons is employed to avoid some of major disadvantages of colloidal carriers systems such as instability in cul de sac and short half life by increasing efficiency of drug encapsulation ...

one of the most significant issues in pharmaceutical industries, prior to commercializationof a pharmaceutical preparation is the “preformulation” stage. however, far too attention hasbeen paid to verification of the software assisted statistical designs in preformulation studies.the main aim of this study was to report a step by step preformulation approach for a semisolidpreparation based on ...

the current methods for treatment of cancers are inadequate and more specific methods such as gene therapy are in progress. among different vehicles, cationic liposomes are frequently used for delivery of genetic material. this investigation aims to prepare and optimize dotap cationic liposomes containing an antisense oligonuclotide (asodn) against protein kinase c alpha in non-small cells lung...

introduction: newborns should be evaluated immediately after birth and the traditional way of assessing is to use the apgar score. the aim of this study was to estimate the apgar score and evaluate the first 24 hour- clinical outcome of babies born at yazd hospitals. methods: in a descriptive cross-sectional study, apgar score was assessed for 462 newborns at the 4 centers of afshar, madar, kar...

receiver operating characteristics (roc) curves have numerous applications for identifying a cut-off point in diagnostic tests. nonetheless, given that sometimes two cut-off points have to be specified simultaneously, the roc curve can be used to identify such points. the volume under the roc surface (vus) serves as a criterion for the accuracy of diagnostic tests. one of the unfortunate outcom...