We analyzed cytogenetically 105 patients with hypocellular primary MDS and their clinical implications. The main chromosomal abnormalities found were del(5q)/-5, del(6q)/+6, del(7q)/-7, del(11q), and del(17p). Pediatric patients had a higher frequency of abnormal karyotypes compared with adult patients (P < 0,05). From our patients, 18% showed evolution of the disease. The chromosomal abnormali...

Correspondencia: Ma Elena Erro Servicio de Neurología Hospital de Navarra C/ Irunlarrea, 3 31008 Pamplona Me gustaría mediante la presente carta hacer una rectificación al último párrafo de la presentación del volumen monográfico sobre las enfermedades del sueño del pasado mes de abril. En dicha presentación comenté que iba a entrar en funcionamiento una unidad de sueño en el Hospital Virgen de...

The deletion of 12p (del(12p)) has been described as a novel negative prognostic marker in multiple myeloma (MM) and has gained increasing attention in recent years. However, its impact on MM is still controversial. In this study, we comprehensively evaluated the clinical impact of 12p13 deletion using fluorescence in situ hybridization (FISH) on 275 newly diagnosed MM cases treated in a prospe...

Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of growth factors that binds to and activates the EGF receptor (EGFR) and ERBB4. Here, we show that HB-EGF-EGFR signaling is involved in eyelid development. HB-EGF expression is restricted to the tip of the leading edge of the migrating epithelium during eyelid closure in late gestation mouse embryos. Both HB-EGF null...

En este art́ıculo presentamos el trabajo llevado a cabo dentro del proyecto de tesis doctoral llamado “Egitura sintaktiko konplexuen identifikazioa eta sinplifikazioa euskararen tratamendu automatikoan” (Identificación y simplificación de las estructuras sintácticas complejas en el procesamiento automático del Euskera) que se realiza bajo la dirección de las doctoras Arantza Dı́az de Ilarraza y M...

CONTEXT Testosterone abuse is conventionally assessed by the urinary testosterone/epitestosterone (T/E) ratio, levels above 4.0 being considered suspicious. The large variation in testosterone glucuronide (TG) excretion and its strong association with a deletion polymorphism in the uridine diphospho-glucuronosyl transferase (UGT) 2B17 gene challenge the accuracy of the T/E ratio test. OBJECTI...

Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that regulates leukocyte recruitment, thereby playing a pivotal role in the regulation of innate and adaptive immunity and tumor progression. Elevated levels of MIF are associated with numerous inflammatory disorders and cancers. To determine whether developmental endothelial locus-1 (Del-1) regulated MIF, RAW264.7 macro...

In this presentation, we review the methodology used in the development of the Galician DBpedia and some of its applications for language processing in the fields of entity recognition and lexical extraction.

Aberrant DNA methylation is a hallmark of cancer but mechanisms contributing to the abnormality remain elusive. We have previously shown that ∆DNMT3B is the predominantly expressed form of DNMT3B. In this study, we found that most of the lung cancer cell lines tested predominantly expressed DNMT3B isoforms without exons 21, 22 or both 21 and 22 (a region corresponding to the enzymatic domain of...

La desambiguación del significado de las palabras se ha desarrollado como una subárea del Procesamiento del Lenguaje Natural (PLN), donde el objetivo es determinar el sentido correcto de aquellas palabras que tienen más de un significado, no es una tarea final en sí misma, sino una tarea intermedia necesaria en variadas aplicaciones del procesamiento del lenguaje natural. La resolución de la am...