1,2-bis-(4-Hydroxy-3-methoxyphenyl)-3-hydroxypropan1-one (evafolin B, 1), 1-(4-hydroxy-3-methoxyphenyl)3-hydroxypropan-1-one (2), were isolated for the first time from the genus Schisandra, along with abscisic acid (3), 4-hydroxybenzaldehyde (4), 4-hydroxybenzoic acid (5), methyl 4-hydroxybenzoate (6), methyl 3,4-dihydroxybenzoate (7), and vanillic acid (8). All the compounds were evaluated for...

Several mechanisms regarding the adverse health effects of nanomaterials have been proposed. Among them, oxidative stress is considered to be one of the most important. Many in vitro studies have shown that nanoparticles generate reactive oxygen species, deplete endogenous antioxidants, alter mitochondrial function and produce oxidative damage in DNA. 8-Hydroxy-2'-deoxyguanosine is a major type...

o-Fructose 1,6-bis(phosphate) aldolase from rabbit muscle (RAMA, 8.C.4.L.2.13) catalyzes the aldol condensation betwe.tr dihyd.oxyacetone phosphate (DHAP) and various aldehydes; the products are ketosugars with 3(S),4iR) stereochemistry. When racemic a-hydroxy aldehydes are condensed with DHAF, two diastereomeric products are formed. This paper demonstrates that RAMA can kinetically resolve a-h...

Four new secondary metabolites, 3α-((E)-Dodec-1-enyl)-4β-hydroxy-5β-methyldihydrofuran-2-one (1), linderinol (6), 4'-O-methylkaempferol 3-O-α-L-(4''-E-p-coumaroyl)rhamnoside (11) and kaempferol 3-O-α-L-(4''-Z-p-coumaroyl)rhamnoside (12) with eleven known compounds-3-epilistenolide D1 (2), 3-epilistenolide D2 (3), (3Z,4α,5β)-3-(dodec-11-ynylidene)-4-hydroxy-5-methylbutanolide (4), (3E,4β,5β)-3-(...

The syntheses of two new spirolactones are described. Each compound was obtained as an off-white solid in 66% yields from 4-hydroxy-3-nitrobenzaldehyde.