BACKGROUND Finding more efficient agents with fewer side effects for treatment of burns has always been a concern for researchers. Silver sulfadiazine (SSD), apparently due to its antimicrobial effect, is still one of the most common prescribed agents. Previous studies suggested that Arnebia euchroma (AE) has shown antimicrobial and anti-inflammatory activities. This study investigates the heal...

ObjectiveOur point is to determine if the treatment of the 3 degree burn wounds makes any difference if sprayed cultured autologous keratinocyte used alone or in combination with Fibrin glue. DesignAnimal experimental study. Animals30 male Wistar rats. ProceduresThirty male Wistar rats were selected and their keratinocytes were isolated and cultured from small skin biopsy. Rats were divided ran...

Antimicrobial therapy remains to be the most important method of wound infection treatment. Systemically administered antimicrobials may not achieve therapeutic level in wound. On the other hand, in the absence of surgical debridement (due to any reason), most topically applied antimicrobials cannot penetrate the wound in therapeutic amount due to the presence of eschar. Burn eschar is a protei...

      Aloe vera is a tropical plant belonging to the Liliaceae family. It has beneficialeffects in variety of diseases. The aim of this study was to formulate a topical cream from A. vera with wound burn healing effect and to perform its clinical trial. A total of 30 patients (20 males and 10 females in the age range of 20-50 years) with second degree burn wounds on their both...

BACKGROUND Autophagy plays a major role in myocardial ischemia and hypoxia injury. The present study investigated the effects of autophagy on cardiac dysfunction in rats after severe burn. METHODS Protein expression of the autophagy markers LC3 and Beclin 1 were determined at 0, 1, 3, 6, and 12 h post-burn in Sprague Dawley rats subjected to 30% total body surface area 3rd degree burns. Autop...

Carlson, Deborah L., D. Jean White, David L. Maass, Robin C. Nguyen, Brett Giroir, and Jureta W. Horton. I B overexpression in cardiomyocytes prevents NFB translocation and provides cardioprotection in trauma. Am J Physiol Heart Circ Physiol 284: H804–H814, 2003; 10.1152/ ajpheart.00394.2001.—This study examined the effects of either I B overexpression (transgenic mice) or N-acetylleucinyl-leuc...