Methotrexate-induced cutaneous ulceration has rarely been reported in patients with mycosis fungoides. We report 4 patients with mycosis fungoides who developed cutaneous ulceration as an initial manifestation of methotrexate toxicity. Methotrexate dose at the time of ulceration ranged from 10-60 mg. All 4 patients were erythrodermic, which may have predisposed them to this toxic effect. It is ...

Thirty-one cases of sporotrichosis diagnosed in the central region of Rio Grande do Sul from 1988 to 1997 were studied. Clinical data were compared with a study concerning three past decades, clearly showing a decrease in the incidence of the mycosis, and an alteration in the profile of the infection, with a decrease of sporotrichosis in rural patients, children, women and farmers. In the past ...

Photodynamic therapy involves the topical application of a photosensitizer to a lesion, which is then subsequently exposed to a light source. It is mainly used in the nonsurgical treatment of nonmelanoma skin cancer, in which it achieves good response and an excellent cosmetic result. In the last 10 years, photodynamic therapy has also been used with some success in the treatment of plaque-stag...

Human mycoses represent infections with an increasing incidence and location due to the increasing number of favourable factors of occurrence such as prolonged and intensive antibiotic therapy, cytostatic therapy, corticosteroid therapy and suppressed immunity. Our study led to important conclusions regarding the incidence of different mycoses among different groups of age and between the two s...

The development of both a T- and B-cell lymphoproliferative disorder in one patient is an unlikely coincidence due to the low prevalence of each malignancy. We report a 65-year-old man with a previously documented history of B hairy cell leukemia, who presented with a new-onset acneiform eruption of his scalp, face, trunk, back, and extremities. Routine pathology of the skin lesions with immuno...