There is a growing body of evidence on the role of nitric oxide (NO) in retinal physiology. Recently, interest has developed in the functional role of an alternative redox form of NO, namely nitroxyl (HNO/NO(-)), because it is formed by a number of diverse biochemical reactions. The aim of the present report was to comparatively analyze the effect of HNO and NO on the retinal nitridergic pathwa...

Bladder cancer (BC) is a common malignancy of the urinary tract that has a higher frequency in men than in women. Cytostatic resistance and metastasis formation are significant risk factors in BC therapy; therefore, there is great interest in overcoming drug resistance and in initiating research for novel chemotherapeutic approaches. Here, we suggest that desethylamiodarone (DEA)-a metabolite o...

OBJECTIVE To evaluate the molecular mechanisms of the inhibitory effects of amiodarone and its active metabolite, desethylamiodarone (DEA) on thyroid hormone action. MATERIALS AND METHODS The reporter construct ME-TRE-TK-CAT or TSHbeta-TRE-TK-CAT, containing the nucleotide sequence of the thyroid hormone response element (TRE) of either malic enzyme (ME) or TSHbeta genes, thymidine kinase (TK...

Bankruptcy assessment provides valuable information for the governments and investors to base their decisions in order to prevent possible financial losses. Data envelopment analysis (DEA) has generally been used to assess relative efficiency of decision making units. Recently, several approaches have appeared that reformulate DEA as a bankruptcy prediction tool. However, only several studies h...

Data Envelopment Analysis (DEA) is a linear programming based technique that was developed to evaluate relative efficiency of nonprofit and public sector Decision Making Units (DMU's) that use multiple inputs to produce multiple outputs. In this study, DEA is evaluated and tested for use as a managerial audit tool to identify and measure inefficiencies among a set of DI'IU's. Based on three app...

Data Envelopment Analysis (DEA) is an approach based on linear programming to assess the relative efficiency of peer Decision Making Units (DMUs). Typically, each DMU is free to choose the weights of the factors used in its evaluation. However, the evaluator’s preferences may not warrant so much freedom. Several approaches have been proposed to allow the incorporation of managerial preferences ...

Data envelopment analysis (DEA) is a non-parametric method for measuring the efficiency of a set of decision making units (DMUs), such as companies or public sector agencies. The main DEA models are only used for positive data. In recent years, some models have been presented to deal with negative data in DEA models. However, these models do not discriminate between efficient DMUs and only eval...

Supplier selection problem (SSP) is a problem to select the best among suppliers based on input and output data of the suppliers. Since different uncontrollable and unpredictable parameters are affecting selection, choosing the best supplier is a complicated process. Data Envelopment Analysis (DEA) is a method for measuring efficiency and inefficiencies of Decision Making Units (DMUs). While, t...

This study evaluates operation performances of 67 international tourist hotels in Taiwan by using the Context-dependent DEA model of Date Envelopment Analysis (DEA) in order to find out the performance of these hotels and their competitive advantages. This study differentiates the levels of efficient frontier with the efficiency of each international tourist hotel. Based on the efficiency, the ...