Trypanosomatid parasites, including Trypanosoma and Leishmania, are the causative agents of lethal diseases threatening millions of people around the world. These organisms compartmentalize glycolysis in essential, specialized peroxisomes called glycosomes. Peroxisome proliferation can occur through growth and division of existing organelles and de novo biogenesis from the endoplasmic reticulum...

De novo peptide sequencing by mass spectrometry represents an important strategy for characterizing novel peptides and proteins, in which a peptide's amino acid sequence is inferred directly from the precursor peptide mass and tandem mass spectrum (MS/MS or MS(3)) fragment ions, without comparison to a reference proteome. This method is ideal for organisms or samples lacking a complete or well-...

principles are identified for it to diffuse (Strang and Meyer 1993). Other scholars have focused on examining how established categories are learned through exemplars that are labeled and grouped, revealing graded (or lenient) rather than dichotomous (or strict) categorical boundaries (Rosch and Mervis 1975, Pontikes 2010). Thus, although we have gained insight into how new categories recombine...

Executive Summary The chronic and severe shortage of skilled Information Technology (IT) workers is well documented. At the same time, many regional and national governments have made the provision of information technology services an important element in their economic development strategies. It is against this background that Georgia Southern University established a School of Information Te...

Aposematic signals that warn predators of the noxious qualities of prey gain their greatest selective advantage when predators have already experienced similar signals. Existing theory explains how such signals can spread through selective advantage after they are present at some critical frequency, but is unclear about how warning signals can be selectively advantageous when the trait is initi...

Family samples, which can be enriched for rare causal variants by focusing on families with multiple extreme individuals and which facilitate detection of de novo mutation events, provide an attractive resource for next-generation sequencing studies. Here, we describe, implement, and evaluate a likelihood-based framework for analysis of next generation sequence data in family samples. Our frame...

Neeraja M. Krishnan, Swetansu Pattnaik, S. A. Deepak, Arun K. Hariharan, Prakhar Gaur, Rakshit Chaudhary, Prachi Jain, Srividya Vaidyanathan, P. G. Bharath Krishna and Binay Panda* Ganit Labs, Bio-IT Centre, Institute of Bioinformatics and Applied Biotechnology, Biotech Park, Electronic City Phase I, Bangalore 560 100, India Strand Life Sciences, Kirloskar Business Park, Bellary Road, Hebbal, B...

OBJECTIVE Greater paternal age is associated with increased risk of schizophrenia, and it has been hypothesized that de novo mutations in paternal germ cells are responsible for this association. An alternative hypothesis is that selection into late fatherhood accompanies a predisposition to schizophrenia. However, direct evidence of either hypothesis is lacking. If de novo mutations are respon...

Despite rapidly decreasing costs and innovative technologies, sequencing of angiosperm genomes is not yet undertaken lightly. Generating larger amounts of sequence data more quickly does not address the difficulties of sequencing and assembling complex genomes de novo. The cotton (Gossypium spp.) genomes represent a challenging case. To this end, a coalition of cotton genome scientists has deve...