2*-b-Fluoro-2*,3*-dideoxyadenosine (F-ddA, lodenosine) is a nucleoside analog that was rationally designed as a more chemically and enzymatically stable anti-AIDS drug than its parent compound 2*,3*-dideoxyadenosine or didanosine. Plasma and cerebrospinal fluid (CSF) pharmacokinetics of this compound and its major metabolite, 2*-b-fluoro-2*,3*-dideoxyinosine (F-ddI), were studied in three rhesu...

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 19, Issue 9 p. 1341-1345 Clinical LetterOpen Access Adjuvant pembrolizumab-related hyperprogression in stage III melanoma Nadine L. Ammann, Ammann Department of Dermatology and Venereology, Skin Cancer Center Hamburg, University Medical Hamburg-Eppendorf, Germany The first two authors contributed equally to the present article.Sear...

Cyclodextrin glycosyltransferase (CGTase) can catalyze the glycosylation of hesperidin, resulting in α-glycosyl hesperidin with significantly improved water solubility. In this study, a rational design CGTase to improve its activity was investigated. The strategy we employed involved docking near-attack conformation and virtually mutating surrounding residues, followed by calculating changes bi...

We propose a new formula for the nonlinear viscous numerical flux and extend direct discontinuous Galerkin method with interface correction (DDGIC) of Liu Yan (H. Liu, J. Yan, The (DDG) diffusion corrections, Communications in Computational Physics 8 (3) (2010) 541) to compressible Navier-Stokes equations. DDGIC framework is based on observation that can be represented as sum multiple individua...

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 19, Issue 3 p. 456-458 Clinical LetterOpen Access Dermatomyositis requires long-term treatment with combined immunosuppressive and immunoglobulin therapy Antonia Wiala, Department for Dermatology Venerology, Rudolfstiftung Hospital, Vienna, AustriaSearch more papers by this authorIgor Vujic, Austria School of Medicine, Sigmund Freu...

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 19, Issue 6 p. 885-888 Clinical Letter Open Access Neglect of the histological diagnostics onychomycosis – best would be so easy Moritz Helfen, Saarland University Medical Center, Dept. Dermatology, Homburg/Saar, GermanySearch for more papers by this authorStefan Wagenpfeil, Institute Biometry, Epidemiology and Informatics, Univers...

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 19, Issue 4 p. 598-602 Clinical LetterOpen Access Vier Fälle einer Erysipel-ähnlichen Entzündung bei Patienten mit metastasiertem Melanom unter Therapie Checkpoint-Inhibitoren Claudia Pföhler, Corresponding Author Pföhler [email protected] Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum des Saarlandes, H...