Introduction Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is an emerging technique for a more accurate assessment of local renal function [1]. However, the measured time intensity curves used for quantification of renal blood flow or glomerlar filtration rate are hampered by motion artefacts, mainly from respiration of the patient [2]. To correct for such motion, image registr...

OBJECTIVE The purpose of this research was to investigate the anti-angiogenic inhibitory effect of KR-31831, a newly developed anti-angiogenic agent, on an in vivo human ovarian carcinoma model using dynamic contrast-enhanced (DCE) MRI. MATERIALS AND METHODS Xenografted ovarian tumors were established by subcutaneous injection of SKOV3 cells into mice. The mice were treated daily with KR-3183...

OBJECTIVES Biologically guided radiotherapy needs an understanding of how different functional imaging techniques interact and link together. We analyse three functional imaging techniques that can be useful tools for achieving this objective. MATERIALS AND METHODS The three different imaging modalities from one selected patient are ADC maps, DCE-MRI, and 18F-FDG PET/CT, because they are wide...

Dynamic contrast enhanced MRI (DCE-MRI) enables the quantitative assessment of tumor status and has found application in both pre-clinical tumor models as well as clinical oncology. DCE-MRI requires the serial acquisition of images before and after the injection of a paramagnetic contrast agent so that the variation of MR signal intensity with time can be recorded for each image voxel. As the a...

This study aims to assess the utility of quantitative dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters in comparison with imaging tumor size for early prediction and evaluation of soft tissue sarcoma response to preoperative chemoradiotherapy. In total, 20 patients with intermediate- to high-grade soft tissue sarcomas received either a phase I trial regimen of sorafen...

BACKGROUND To investigate dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for assessing histopathological and molecular biological features in induced rat epithelial ovarian carcinomas (EOCs). METHODS 7,12-dimethylbenz[A]anthracene (DMBA) was applied to induce EOCs in situ in 46 SD rats. Conventional MRI and DCE-MRI were performed to evaluate the morphology and perfusion featur...

Introduction: The ability to image tumour hypoxia and evaluate oxygenation changes in response to treatment using R2* is a powerful yet underexplored tool in breast cancer in humans [1]. This study evaluates the relationship between baseline histology and dynamic contrast enhanced (DCE) and dynamic susceptibility enhanced (DSC) MRI parameters with R2* in breast cancer. The role of R2* as an ima...

OBJECTIVE There are no long-term medical treatments for uterine fibroids, and non-invasive biomarkers are needed to evaluate novel therapeutic interventions. The aim of this study was to determine whether serial dynamic contrast-enhanced MRI (DCE-MRI) and magnetization transfer MRI (MT-MRI) are able to detect changes that accompany volume reduction in patients administered GnRH analogue drugs, ...

Accurate pharmacokinetic (PK) modeling of dynamic contrast enhanced MRI (DCE-MRI) in prostate cancer (PCa) requires knowledge of the concentration time course of the contrast agent in the feeding vasculature, the so-called arterial input function (AIF). The purpose of this study was to compare AIF choice in differentiating peripheral zone PCa from non-neoplastic prostatic tissue (NNPT), using P...

Introduction: Dynamic contrast-enhanced (DCE) MRI is extensively evaluated to assess the potential of biomarkers characterizing tumor microvasculature. Current pharmacokinetic models used with clinically approved small molecular weight contrast agents (CA) yield transfer constants (K) which generally depends on both, capillary permeability and blood flow. In pre-clinical studies, DCE MRI is typ...