Recently, we developed a framework, namely Multi-hop TDD CAC and DCA (MTCD), for optimal centralized DCA in multi-hop 4G/4G+ UTRA TDD networks. We also proposed two CAC schemes that use a pre-defined optimization algorithm to ensure that admission is based, to a large extent, on topology maintenance, energy conservation, load balancing, and fairness. In this paper, we address the centralized li...

Solid tumors, including the aggressive primary brain cancer glioblastoma multiforme, develop resistance to cell death, in part as a result of a switch from mitochondrial oxidative phosphorylation to cytoplasmic glycolysis. This metabolic remodeling is accompanied by mitochondrial hyperpolarization. We tested whether the small-molecule and orphan drug dichloroacetate (DCA) can reverse this cance...

The cell growth inhibition induced by bile acid deoxycholic acid (DCA) may cause compensatory hyperproliferation of colonic epithelial cells and consequently increase colon cancer risk. On the other hand, there is increasing evidence for the efficacy of certain forms of selenium (Se) as anticancer nutrients. Methylselenol has been hypothesized to be a critical Se metabolite for anticancer activ...

We examined the effect of hypoxia on apoptosis of human colorectal cancer (CRC) cells in vitro and in vivo. All cell lines tested were susceptible to hypoxia-induced apoptosis. DCA treatment caused significant apoptosis under normoxia in SW480 and Caco-2 cells, but these cells displayed decreased apoptosis when treated with DCA combined with hypoxia, possibly through HIF-1alpha dependent pathwa...

• For many years it has been recognized that normal human subjects and normal dogs retain salt and water only transiently and fail to develop edema during the chronic administration of large doses of a sodium-retaining hormone such as desoxycorticosterone acetate ( DCA ). Similarly, some Addisonian patients retain Na for only a few days in response to prolonged administration of DCA or aldoster...

Trichloroethylene (TCE) has been identified as an environmental contaminant in groundwater. Trichloroacetic acid (TCA), dichloroacetic acid (DCA), chloral hydrate (CH), trichloroethanol (TCOH), and trichloroethanol glucuronide (TCOG) have been identified as metabolites of TCE. Studies have shown that TCA and DCA are toxicologically significant metabolites that can induce liver tumors in B6C3F1 ...

Ultrasonography was used to measure flexor tendon sheath thickness in 14 insulin-dependent (IDDM) diabetics with diabetic cheiroarthropathy (DCA) and compared to 17 IDDM patients without DCA along with 10 healthy volunteers. Assessment was also made of the presence of systemic diabetic microvascular disease complications. A blinded visual 'eyeball' report on the ultrasound scans by a radiologis...

The small, water soluble molecule Dichloroacetate (DCA) is recently arousing lively interests in the field of cancer therapy for it has been shown to be able to inhibit the growth of human tumors acting specifically on the mitochondria of cancer cells without perturbing the physiology of nonmalignant cells. Neuroblastoma was one of the tumor types on which DCA was considered ineffective as it i...

Motivated by a scheduling problem encountered in multicast environments, we study a vertex labelling problem, called Directed Circular Arrangement (DCA), that requires one to find an embedding of a given weighted directed graph into a discrete circle which would minimize the total weighted arc length. Its decision version is already known to be NP-complete when restricted to sparse weighted dir...