Dual and triple activity-difference (DAD/TAD) maps are twoand threedimensional representations of the pairwise activity differences of compound data sets, respectively [1]. These maps are valuable tools for the systematic characterization of structure-activity relationships (SAR) of compounds data sets screened against two or three targets [2]. Adding pairwise structural similarity information ...

RATIONALE A revised definition of clinical criteria for acute respiratory distress syndrome (ARDS), the Berlin definition, was recently established to classify patients according to their severity. OBJECTIVE To evaluate the accuracy of these clinical criteria using diffuse alveolar damage (DAD) at autopsy as the reference standard. METHODS All patients who died and had a clinical autopsy in...

OBJECTIVE To analyze the association between drug (DAD) and alcohol (AAD) abuse and dependency and criminal and clinical background by gender of prisoners in São Paulo, Brazil. METHOD Cross-sectional study, random sample stratified by administrative district, from which prisons and prisoners were selected via random, multistage sampling. Psychiatric diagnoses were made with the CIDI 2.1. Life...

intensify the pulmonary toxicity of MTX is unclear. RA itself can also affect the lung [6] usually leading to an interstitial pneumonia, either lymphocytic or chronic non-specific with various degrees of organizing pneumonia. None of these features was seen in the presented case. UIP and non-specific interstitial pneumonia (NSIP) could be ruled out as well. Also, the process did not fulfil the ...

OBJECTIVE To identify medications that have a high risk of adverse drug effects (ADEs) among seniors, using data from publicly available administrative databases. DESIGN Cross-sectional study using the Discharge Abstracts Database (DAD) (which contains data on acute care institutions in all provinces and territories except Quebec), the National Ambulatory Care Reporting System (NACRS) (which ...

Soon after my father died in 2006, we sat down to describe the kind of man he was so that the rabbi could prepare the service and eulogy. My dad was the kind of father who somehow was always there when needed despite working 6 days and several late evenings eachweek. Dad never seemed too tired to help with homework, hear about your day, and give you a hug. When we were adults with homes of our ...

BACKGROUND The medicinal importance of a novel plant Olax nana Wall. ex Benth. (family: Olacaceae) was revealed for the first time via HPLC-DAD finger printing, qualitative phytochemical analysis, antioxidant, cholinesterase, and α-glucosidase inhibitory assays. METHODS The crude methanolic extract of O. nana (ON-Cr) was subjected to qualitative phytochemical analysis and HPLC-DAD finger prin...