Patent ductus arteriosus is frequent in premature babies. With an incidence of 1:2500-5000, it accounts for 9% to 12% of congenital heart disease. Several different drugs have been tried for closure of hemodynamically significant patent ductus arteriosus. The first to be used was indomethacin, with a success rate of 70% and a reopening rate of 35%; however, the high cost of this drug has driven...

Reopening of the ductus arteriosus after successful indomethacin-induced closure has become a major problem with indomethacin treatment. In full-term human newborns and lambs, the ductus behaves like ischemic tissue after its initial constriction. Its ability to continue to relax or contract depends on the amount of left-to-right shunt through the ductus lumen. To see if ductus constriction in ...

Reopening of the ductus arteriosus after successful indomethacin-induced closure has become a major problem with indomethacin treatment. In full-term human newborns and lambs, the ductus behaves like ischemic tissue after its initial constriction. Its ability to continue to relax or contract depends on the amount of left-to-right shunt through the ductus lumen. To see if ductus constriction in ...

Patent ductus arteriosus (PDA) is a common diagnosis among extremely premature infants, especially in those with lung disease. Treatments are often used to close the PDA. Despite nearly three decades of research, the question of whether the benefits of treatments to prevent ductal patency or promote closure outweigh the risks of these treatments remains unanswered. The authors rarely use treatm...

Dye dilution and cardiac catheterization technics were used to study 36 patients with a central left-to-right shunt due to patent ductus arteriosus, atrial septal defect or ventricular septal defect. The configuration of dilution curves following injection of dye into an antecubital vein was similar in all instances. Principal abnormalities of the curve were a prolongation of its disappearance ...

The study of the anatomic and hemodynamic relationships in a case of coaretation of the aorta complicated by patency of the ductus arteriosus and pulmonary hypertension indicated the necessity for a physiologic approach to the classification of coarctation of the aorta. The origin of existing classifications has been briefly traced and basic anatomic and physiologic considerations in this malfo...

The heterotaxy syndrome is a rare and sporadic disorder. This syndrome presents with situs ambiguus, splenic malformations such as asplenia or polysplenia, and congenital heart disease. Congenital heart diseases associated with this syndrome include a broad variety of manifestations. Patent ductus arteriosus is one of them and percutaneous transcatheter closure can be challenging in the setting...

tion in which there is narrowing or complete obliteration at or below the isthmus of the aorta; that part of the aorta which extends between the origin of the left subclavian artery and the point of insertion of the ductus arteriosus. Bonnet classifies coarctation of the aorta under two headings :? (1) Infantile type in which there is a diffuse narrowing of the isthmus, and is usually associate...

This rare congenital malformation is a round or oval opening between the ascending aorta and the main pulmonary artery above the semilunar valves. It is practically impossible to differentiate this malformation from a patent ductus arteriosus clinically because both malformations may present the same physical, fluoroscopic, roentgen and electrocardiographic findings. Even angiocardiography and ...

The diagnosis of patent ductus arteriosus is difficult when the classic continuous murmur is not present. In infancy, in the presence of cardiac decompensation and when the ductus approximates the aorta in size, the continuous murmur is frequently absent. A correct diagnosis may be important, however, for a large patent ductus arteriosus can cause serious difficulty. Early surgical treatment ma...