OBJECTIVE Most gain of function mutations of tyrosine kinase receptors in human tumours are hemizygous. Gastrointestinal stromal tumours (GIST) with homozygous mutations have a worse prognosis. We aimed to identify genes differentially regulated by hemizygous and heterozygous KIT mutations. MATERIALS AND METHODS Expression of 94 genes and 384 miRNA was analysed with low density arrays in five...

We study the effects of adding RR, NS and metric fluxes on a T/(Ω(−1)LI3) Type IIA orientifold. By using the effective flux-induced superpotential we obtain Minkowski or AdS vacua with broken or unbroken supersymmetry. In the Minkowski case some combinations of real moduli remain undetermined, whereas all can be stabilized in the AdS solutions. Many flux parameters are available which are uncon...

Recently a class of Type IIA orientifold models was constructed yielding just the fermions of the SM at the intersections of D6-branes wrapping a 6-torus. We generalize that construction to the case of Type IIB compactified on an orientifold of T × (C/ZN) with D5-branes intersecting at angles on T. We construct explicit models in which the massless fermion spectrum is just the one of a three-ge...

Rate coefficients for terminal acetate (g-O2CCH3) substitution from the [Mo3(l3-O)2(l-O2CCH3)6 (g-O2CCH3)3] anion were examined in polar protic (D2O and methanol-d4), polar aprotic (DMSO-d6 and DMF-d7) and acidic solvents (acetic acid-d4). Reaction rates were determined using variable-temperature H NMR and found to span orders of magnitude depending on the solvent (k K (s!1) = 7.2 " 10!6 for D2...

By means of geometrical classification ([22]) of space of initial conditions, it is natural to consider the three types, PIII(D6), PIII(D7) and PIII(D8), for the third Painlevé equation. The fourth article of the series of papers [17] on the Painlevé equations is concerned with PIII(D6), generic type of the equation. The other two types, PIII(D7) and PIII(D8) are obtained as degeneration from P...

We consider type IIA string theory on a Calabi-Yau 2-fold with D6branes wrapping 2-cycles in the 2-fold. We find a complete set of conditions on the supergravity solution for any given wrapped brane configuration in terms of SU(2) structures. We reduce the problem of finding a supergravity solution for the wrapped branes to finding a harmonic function on R×CY2. We then lift this solution to 11-...

We study the Fayet-Iliopoulos (FI) D-terms on D-branes in type II Calabi-Yau backgrounds. We provide a simple worldsheet proof of the fact that, at tree level, these terms only couple to scalars in closed string hypermultiplets. At the one-loop level, the D-terms get corrections only if the gauge group has an anomalous spectrum, with the anomaly cancelled by a Green-Schwarz mechanism. We study ...

The straightforward identification of impurity signals in nuclear magnetic resonance (NMR) spectra is imperative for the structure elucidation and signal assignment synthetic products intermediates. To keep pace with emergence novel green solvents auxiliary compounds (e.g., acids bases), NMR tables databases must be regularly updated. This study reports residual 1H 13C chemical shifts 42 solven...

We construct new families of $\text{AdS}_2 \times S^2 S^2$ solutions with 4 supercharges in Type II supergravities. show that subclasses these can be interpreted terms defect branes embedded 4d $\mathcal{N} = $ SYM, or orbifolds thereof. This is explicitly realised by showing the asymptote locally to $\text{AdS}_5 S^5/\mathbb{Z}_n$, IIB, its T-dual background, IIA. The latter a Gaiotto-Maldacen...

Abstract Study question Is there an association between mitochondrial DNA (mtDNA) content and Ongoing Pregnancy Rate (OPR) in D5 or D6 euploid blastocyst? Summary answer Day6 OPR is decreased high mtDNA blastocyst. Day5 levels are independent of maternal age standard morphology. What known already Preimplantation development energy-demanding process ATP production crucial for cellular activity ...