INTRODUCTION Most denture base acrylic resins have polymethylmethacrylate in their composition. Several authors have discussed the polymerization process involved in converting monomer into polymer because adequate polymerization is a crucial factor in optimizing the physical properties and biocompatibility of denture base acrylic resins. To ensure the safety of these materials, in vitro cytoto...

Idiopathic thrombocytopenic purpura is a chronic autoimmune hematological disease caused by an increased destruction of platelets and associated thrombocytopenia, for the treatment which imported drug romiplostim used. Сreation biosimilar provides reduction in cost therapy access to more patients. The aim study was compare safety indicators reference its vivo vitro. Materials methods. In vitro ...

background: aurones are naturally occurring compounds that belong to flavenoids family and have antiplasmodial effects. this study investigated some new aurones derivatives against chloroquine sensitive plasmodium falciparum. here we report the synthesis , in vitro antiplasmodial activity and cytotoxic evaluation of 11 compound from derivatives of (z)-2- benzylidene-4, 6-dimethoxybenzofuran-3(2...

background: we aimed at evaluating the toxicity effects of low (subtoxic) concentrations of silver nanoparticles (agnp, 5-10 nm) in human hepatoblastoma (hepg2) cell line after and during a period of about one month. methods: xtt and mtt assays were used to draw a dose-response curve ic50 (half maximal inhibitory concentration) value of the agnp on hepg2 cells was calculated to be 2.75-3.0 mg/l...

INTRODUCTION Despite the known importance of Clostridium difficile as a nosocomial pathogen, few studies regarding Clostridium difficile infection (CDI) in Brazil have been conducted. To date, the diagnostic tests that are available on the Brazilian market for the diagnosis of CDI have not been evaluated. The aim of this study was to compare the performances of four commercial methods for the d...

introduction: mineral trioxide aggregate is being widely used for root end filling, pulp capping, perforation repair, and other endodontic procedures. recently, a material similar to proroot mineral trioxide aggregate (pmta) was developed in iran named root mineral trioxide aggregate (rmta) with the claim of having the exact result of original mta. the purpose of this study was to compare the a...

background: the use of natural products as anticancer and antioxidant agents has a long history. several drugs currently used in chemotherapy were isolated from plant species. objective: the aim of this study was to evaluate cytotoxicity and antioxidant activity as well as phenol and flavonoid contents of five plant species of solanaceae family. methods: five plant species of solanaceae family ...

background and objectives: there is a profound inclination among people toward consumption of herbs and herbal products. some of these products are harmful while health-promoting potentials of some others should be discovered. in the present study the antibacterial, antioxidant, acute and subchronic and cancer cell toxicity of methanolic and aqueous extracts of rosa damascena mill. was studied....

several cycline dependent kinase 2 (cdk2) inhibitors with different chemical structures have been introduced. the hinge region of cdk2 (residues 81–84) contains a set of hydrogen bond donor and acceptor sites some of which must be satisfied for potent inhibitor binding. the benzimidazolone skeleton may provide such interactions. accordingly, 3-sulfonamide substituted benzamido-benzimidazolones ...