BACKGROUND AND OBJECTIVES Flow cytometric immunophenotypic analysis (FC) and cytogenetic analysis are essential techniques for the diagnosis and classification of many hematologic disorders. The roles of these analyses in B-cell lymphoma to detect bone marrow (BM) involvement in clinical staging and to evaluate the effectiveness of treatments have not yet been determined. The aim of this study ...

Introduction: Cytogenetic abnormalities are one of the important causes recurrent pregnancy loss or bad obstetric history and Infertility. Almost 50% first trimester upto 20% second can be due to cytogenetic cause. At same time, also detected in2-3% cases with infertility especially in males. Methods: In this paper, wepresent our detailed analysisof13,618 Bad Obstetric History (BOH) cases,refer...

An extra G band was found inserted into chromosome 11q23.2 in a boy who had severe developmental delay and anal stenosis. Cytogenetic characterisation of this extra band showed that it was composed of Q band brilliant, C band heterochromatin. It was also present in clinically normal subjects in two other generations and was therefore presumed to be unrelated to the clinical abnormalities in the...

Acute myeloid leukaemia (AML) is a heterogeneous disease covering a range of morphological lineages and differentiation stages, but also has number of recurrent chromosomal abnormalities and mutations associated with prognosis. Because of the defined molecular and cytogenetic features, AML has been a focus of gene expression profiling studies and identified differentially expressed genes in the...

In this issue of Blood, Middeke et al, for the well-regarded Cooperative German Study Group, report a retrospective analysis in which they demonstrate that a hierarchial classification system for specific cytogenetic abnormalities in acute myeloid leukemia (AML) reveals that patients with abnormal 17p [abnl(17p)] and -5/5q- abnormalities have worse outcomes after allogeneic hematopoietic cell t...

BACKGROUND The recent study described a better outcome in acute promyelocytic leukemia patients treated with all-trans retinoic acid and arsenic oxide compared to those treated with all-trans retinoic acid combined with conventional chemotherapy. The pivotal study indicated that favorable-risk acute promyelocytic leukemia patients can be cured without any cytotoxic chemotherapy. Even high-risk ...

BACKGROUND AND OBJECTIVES Myelodysplastic syndrome (MDS), secondary acute myeloid leukemia (sAML) and clonal karyotypic abnormalities, have been recognized as relatively frequent and potentially serious complications of autologous peripheral blood progenitor cell transplantation (PBPCT) for Hodgkin's disease (HD), non-Hodgkin's lymphoma (NHL) or multiple myeloma (MM). DESIGN AND METHODS We an...

Trisomy 8 mosaicism syndrome (T8MS ) is a rare chromosome disorder caused by the presence of extra in some cells body. T8MS clinically variable condition associated with number developmental abnormalities. We report dysmorphic features and congenital anomalies. A 3.5-month-old boy was referred to genetic department because his atypical facial appearance. Physical examination revealed microcepha...

BACKGROUND We comprehensively profiled cytogenetic abnormalities in multiple myeloma (MM) and analyzed the relationship between cytogenetic abnormalities of undetermined prognostic significance and established prognostic factors. METHODS The karyotype of 333 newly diagnosed MM cases was analyzed in association with established prognostic factors. Survival analysis was also performed. RESULT...

Treatment-related myelodysplastic syndrome (t-MDS) and acute myelogenous leukemia (t-AML) are now well established as complications of cytotoxic chemotherapy. We experienced a 28-yr-old female patient who developed t-MDS/t-AML with characteristic chromosomal abnormalities including 11q23 chromosomal rearrangement following high-dose chemotherapy with autologous stem cell transplantation (ASCT) ...