BACKGROUND Patients with suspected or confirmed non-ST-elevation acute coronary syndrome (ACS) constitute a large and heterogeneous group. Measurements of renal function such as serum creatinine and estimation of creatinine clearance carry independent prognostic information in this population. Cystatin C is a new and better marker of renal function than creatinine. The aim was therefore to eval...

BACKGROUND There is still an ongoing discussion on the prognostic value of cystatin C in assessment of kidney function. Accordingly, the present study aimed to conduct a meta-analysis to provide evidence for the prognostic value of this biomarker for acute kidney injury (AKI) in children. METHODS An extensive search was performed in electronic databases of Medline, Embase, ISI Web of Science,...

BACKGROUND Early identification of impairment in renal function is crucial in diabetic patients. Serum cystatin C may be the most sensitive indicator of glomerular filtration rate (GFR) in the clinical setting. METHODS We compared cystatin C with creatinine, the Cockcroft-Gault (C-G) formula, and the Modification of Diet in Renal Disease (MDRD) study equation for the assessment of early decre...

OBJECTIVES There is no literature available on the performance of cystatin C in Chronic Kidney Disease (CKD) patients of Indian population based on age group. Hence, this study is aimed to compare the diagnostic performance of serum cystatin C and creatinine with measured glomerular filtration rate (GFR) and estimated GFR (eGFR) in subjects of Indian origin. METHODS The study was carried out ...

BACKGROUND Decreased renal function is an established risk factor for cardiovascular disease (CVD). Causal mechanisms between estimates of renal function and CVD are intricate and investigation of the relative importance of genetic and environmental factors for the variability of these phenotypes could provide new knowledge. METHODS AND RESULTS Cystatin C and creatinine levels in 12 313 twins...

The levels of cysteine proteinase inhibitors stefin A, stefin B, and cystatin C were determined using ELISAs in sera obtained preoperatively from 345 patients with colorectal cancer and in control sera from 125 healthy blood donors. The levels of stefin A and cystatin C were found to be moderately increased in patient sera (1.4-fold and 1.6-fold, respectively; P < 0.0001), whereas the level of ...

Cathepsin Enzymes and Cystatin C: Do They Play a Role in Positive Arterial Remodeling? To the Editor: We have read the impressive article recently published by Aoki et al1 evaluating the cathepsin enzyme system in cerebral aneurysm formation. By using quantitative RT-PCR and immunohistochemistry, the authors have demonstrated increased expression of cathepsin B, cathepsin K, and cathepsin S in ...

BACKGROUND Chronic kidney disease (CKD) diagnosis relies on glomerular filtration rate (eGFR) estimation, traditionally using the creatinine-based Modification of Diet in Renal Disease (MDRD) equation. The Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) equation performs better in estimating eGFR and predicting mortality and CKD progression risk. Cystatin C is an alternative glomerul...

This article looks at the value of cystatin C in assessing renal function in older people. While it appears to be reliable and accurate, it is still relatively untested in most clinical settings and there is much to learn before its value in the day-to-day assessment of renal function can be determined.

BACKGROUND Serum creatinine as a classic marker of renal function has several limitations in the detection of renal dysfunction. OBJECTIVES This study assessed the validity of serum cystatin C as a marker of renal function in critically ill patients with normal serum creatinine. PATIENTS AND METHODS Eighty adult patients referred to intensive care units with serum creatinine levels < 1.5 mg...