Skin is the outmost barrier that separates human body from external environment. In psoriasis, immune cells are resident and / or infiltrated into epidermis in order to form epidermal immunological microenvironment (EIME) constitute a complex interaction with keratinocytes, together nerve microbiota influence. Our results have shown psoriasis mainly mediated by specific inflammatory environment...

Dermatology is a broad specialty, and clinical trial resources are limited. We sought to describe current disease focus resource allocation. tabulated trials from 5 dermatology journals (JAMA Dermatology, BJD, JID, JAAD, JEADV) 2015-2019. Study characteristics, funding, were extracted. Results descriptive, associations with industry funding investigated logistic regression. 265 met inclusion cr...

A mechanistic model for lactose/H(+) symport via the lactose permease of Escherichia coli proposed recently indicates that the permease must be protonated to bind ligand with high affinity. Moreover, in the ground state, the symported H(+) is shared between His-322 (helix X) and Glu-269 (helix VIII), whereas Glu-325 (helix X) is charge-paired with Arg-302 (helix IX). Substrate binding at the ou...

The analysis of the corpus letters emperor Constantine, in particular, one he addressed to synod Arles 314, Church Nicomedia 325 and Arius 333, Eusebius Caesarea’s account Synod Nicaea 325, allows evaluate evolution theological representations first Christian emperor. Constantine’s interest was not only political, but also able listen understand milestones controversy.

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. clicking here colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others . here following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles (this information is current as of June 9, 2010 ): The following resources related to this article are available online at www.sc...

BACKGROUND Although treatment with immediate aspirin reduces morbidity and mortality in ST-elevation myocardial infarction, the optimal dose is unclear. We therefore compared the acute mortality and bleeding risks associated with the initial use of 162 versus 325 mg aspirin in fibrinolytic-treated ST-elevation myocardial infarction patients. METHODS AND RESULTS Using combined data from the Gl...

. clicking here colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others . here following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles (this information is current as of January 11, 2010 ): The following resources related to this article are available online at ww...