BACKGROUND Elderly patients on haemodialysis have a high prevalence of polypharmacy and are at risk of drug-related complications. More than 80 % of all prescribed drugs are metabolized by the cytochrome P450 (CYP) enzyme system. The aims of this study were to describe the prevalence of polymorphism in three CYP isoenzymes and the relationship between CYP polymorphism and prescribed drugs. ME...

Sirolimus is an immunosuppressive drug currently used alone or in combination with cyclosporine. Both drugs undergo extensive metabolism by the CYP 3A enzymes. This study aimed at comparing the activity of recombinant CYP (rCYP) 3A4 and 3A5 toward sirolimus, investigating the effect of cyclosporine on the metabolic rate of these two cytochromes P450 (P450s), as well as the impact of the CYP 3A5...

Previous studies demonstrated changes in urinary bladder neurotrophin content and upregulation of neurotrophin receptors, TrkA and the p75 neurotrophin receptor (p75(NTR)), in micturition reflex pathways after cyclophosphamide (CYP)-induced cystitis. p75(NTR) can bind nerve growth factor (NGF) and modulate NGF-TrkA binding and signaling. We examined p75(NTR) expression and the role of p75(NTR) ...

background apo-lipoprotein e (apoe) and carnitine palmitoyltransferase1-a (cpt1-a) genes are well known to be involved in the pathophysiology of psychiatric disorders such as schizophrenia but regarding their cpg island methylation status data is sparse. objectives the aims of the current study were to highlight the effect of the promoter “hypermethylation” in the development of scz. patients a...

conclusions this study showed that ifnβ-1a decreased oxidant impacts in ms patients, but had no influence in improving mitochondrial dysfunction. results in the patients group (30 patients), a significant difference was observed in their measured biochemical factors in comparison to the control group (p = 0.001), however, after six months of using ifnβ-1a, only mda was shown in the main (p = 0....

Hydroxylations of pregnenolone (PREG) at the 7 alpha- and 7 beta-positions have been reported in numerous murine tissues and organs and responsible cytochrome P450 (CYP) species await identification. Using thin layer chromatography and gas chromatography-mass spectrometry, we report identification of 7 alpha-hydroxy-PREG and 7 beta-hydroxy-PREG metabolites produced in mouse brain microsome dige...

PURPOSE There is a strong scientific rationale to support the view that cytochrome P450 (CYP P450) enzyme-inducing AEDs induce bone loss in patients with epilepsy. However, no study has investigated the association between CYP 2C9 polymorphism and bone mineral density (BMD), 25-hydroxyvitamin D or parathyroid hormone levels in patients with epilepsy. This study sought to determine the associati...

Cytochrome P450 mediated metabolism of methyleugenol to the proximate carcinogen 1'-hydroxymethyleugenol has been investigated in vitro. Kinetic studies undertaken in liver microsomes from control male Fischer 344 rats revealed that this reaction is catalyzed by high affinity (Km of 74.9 +/- 9.0 microM, Vmax of 1.42 +/- 0.17 nmol/min/nmol P450) and low affinity (apparent Km several mM) enzymic ...

Looked after children (LAC) are and young people (CYP) who have been under the continuous care of local authority for more than 24 hours. Reasons becoming looked include concerns about abuse or neglect, breakdown in family functioning, absence a suitable caregiver (for example bereavement, parental illness, separation, such as unaccompanied asylum-seeking children). Many LAC live with foster fa...