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Background—The multidrug resistance phenomenon results from the expression of P-glycoprotein (P-gp), a drug-eZux pump. Corticosteroids are substrates for P-gp, whose function can be inhibited by cyclosporin. This study evaluates the ability of cyclosporin to modulate dexamethasone uptake in multidrug resistant cells. Methods—The K 562 cell line, which does not express P-gp and a P-gp expressing...

background: to evaluate the effect of cyclosporin a (csa) and angiotensin ii (ang ii) on cytosolic calcium levels in cultured human gingival fibroblasts (hgfs). materials and methods: healthy gingival samples from six volunteers were obtained, and primary hgfs were cultured. cell viability and proliferation assay were performed to identify the ideal concentrations of csa and ang ii. cytosolic c...

A total of 42 patients who had failed prior renal transplantation underwent repeat cadaveric transplantation using cyclosporin A and low dose steroid immunosuppression. Patient survival at 1 year was 100 per cent. Over-all graft survival was 83 per cent at 1 year, which was significantly better than had been obtainable previously in this high risk group. Repeat cadaver transplantation with cycl...

1. Armstrong VW, Oellerich M. New developments in the immunosuppressive drug monitoring of cyclosporine, tacrolimus, and azathioprine. Clin Biochem 2001;34:9–16. 2. Kahan BD, Keown P, Levy GA, Johnston A. Therapeutic drug monitoring of immunosuppressant drugs in clinical practice. Clin Ther 2002;24:330–50. 3. Oellerich M, Armstrong VW. Two-hour cyclosporine concentration determination: an appro...