Hypertension is associated with endothelial dysfunction that is attributable to oxidative stress and a proinflammatory state. Under these conditions, enhanced expression of cyclooxygenase-2 might lead to increased production of vasoconstrictor prostanoids and reactive oxygen species that reduce the bioavailability of endothelium-derived nitric oxide. To investigate the contribution of cyclooxyg...

IN a subset of patients with asthma, nonsteroidal antiinflammatory drugs (NSAIDs) that inhibit both cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) can precipitate dangerous asthmatic attacks. It has been proposed that in these patients, the attacks are triggered by inhibition of COX-1 and not COX-2, and that the use of highly selective COX-2 inhibitors may be safe in asthmatic patients, ...

A substantial amount of evidence has proposed an important role for Cyclooxygenase-2 (COX-2) enzyme in brain diseases and affiliate disorders. The purpose of this research was studying the effects of COX-2 selective inhibition on haloperidol-induced catatonia in an animal model of drug overdose and Parkinson’s disease (PD). In this study, the effect of acute and Sub-chronic oral administration ...