The damage mechanisms of cross-ply laminates under fatigue loading have been deeply studied during last years. In the case quasi-static loads so-called scale effect has recently acquired renewed importance after appearance ultra-thin plies. this work, experimental observation onset transverse and its progression in two different tension–tension cyclic is performed. First, a [04/903/04] laminate...

To study the mechanical and energy evolution characteristics of sandstone under true triaxial cyclic loading, a test with different intermediate principal stress loading was conducted using rock disturbance unloading system. The influence axial load on deformation, evolution, macroscopic failure in systematically analyzed, damage law revealed. Results showed that mode compression changed from t...

In a previous communication, we showed that beta-adrenergic stimulation of cardiac muscles was associated with an increase in the rate of cycling of crossbridges as measured by perturbation analysis in the frequency domain. In this analysis, the frequency at which dynamic stiffness is a minimum (fmin) is taken as a measure of the rate of crossbridge cycling. In this paper, we test the hypothesi...

Additive manufacturing technologies are in the process of establishing themselves as an alternative production technology to conventional manufacturing, such as casting or milling. Especially laser additive manufacturing (LAM) enables the production of metallic parts with mechanical properties comparable to conventionally manufactured components. Due to the high geometrical freedom in LAM, the ...

The influence of tubule orientation on the transition from fatigue to fatigue crack growth in human dentin was examined. Compact tension (CT) and rectangular beam specimens were prepared from the coronal dentin of molars with three unique tubule orientations (i.e., 0 degrees , 45 degrees and 90 degrees). The CT specimens (N=25) were used to characterize fatigue crack initiation and steady-state...

Mechanical forces play an important role in shaping the organization of the extracellular matrix (ECM) in developing and mature tissues. The resulting organization gives the tissue its unique functional properties. Understanding how mechanical forces influence the alignment of the ECM is important in tissue engineering, where recapitulating the alignment of the native tissue is essential for ap...

The cyclic mechanical effect of airflow during breathing creates the optimal airway hydration state. MUC (mucin) 5AC is an important component of the airway mucus. The formation of MUC5AC is related to ATP and intracellular calcium in the epithelial cells. In this study, we evaluated the effect of ATP release from intracellular calcium in epithelial cells on cyclic pressure-induced mucus secret...

BACKGROUND AND PURPOSE NG-substituted analogues of L-arginine are potent and selective inhibitors of nitric oxide synthase(s). The present study was designed to determine the effects of these analogues on the vascular smooth muscle of isolated canine basilar arteries. METHODS Basilar artery rings without endothelium were suspended for isometric tension recording in Krebs-Ringer bicarbonate so...

A mesenchymal stem cell (MSC)-seeded collagen gel under static or dynamic tension is a well-established model to study the potential of MSCs in regenerating a tendon- or ligament-like tissue. Using this model, upregulation of fibrillar collagen mRNA expression and protein production has been demonstrated in response to cyclic tensile mechanical stimulation. However, the mechanisms driving MSC t...

Sutures are fibrous connective tissue articulations between intramembranous craniofacial bones. Sutures are composed of fibroblastic cells with their matrices in the center and osteogenic cells in the periphery producing a matrix that is mineralized during skeletal growth. Whether oscillatory forces stimulate sutural growth is unknown. In the present work, we applied static and cyclic forces wi...