Abstract A new method to synthesize complexes of the type [(CNC)Ru II (NN)L] n+ has been introduced, where CNC is a tridentate pincer composed two (benz)imidazole derived NHC rings and pyridyl ring, NN bidentate aromatic diimine ligand, L=bromide or acetonitrile, n=1 2. Following this series six synthesized characterized by spectroscopic, analytic, crystallographic, computational methods. Their...

β-ketoimines are extensively applied for the synthesis of organometallic complexes intended as (pre)catalysts a variety chemical transformations. We were interested in two Cr bearing simple bidentate β-ketoimine (L), with different ligand binding modes, well their application precatalyst polymerization olefins. Complex 1 (L2CrCl3) was obtained by direct reaction L CrCl3(THF)3, while, complex 2 ...

A new C2-symmetrical P-chirogenic bisphosphine ligand with silyl substituents on the backbone, (R,R)-5,8-TMS-QuinoxP*, has been developed. This showed higher reactivity and enantioselectivity for direct enantioconvergent borylation of cyclic allyl electrophiles than its parent ligand, (R,R)-QuinoxP* (e.g., a piperidine-type substrate: 95% ee vs 76% ee). The borylative kinetic resolution linear ...

Cyclic nucleotide-gated (CNG) channels conduct NaF, KF and Ca2F currents under the control of cGMP and cAMP. Activation of CNG channels leads to depolarization of the membrane voltage and to a concomitant increase of the cytosolic Ca2F concentration. Several polypeptides were identified that constitute principal and modulatory subunits of CNG channels in both neurons and non-excitable cells, co...

In cyclic nucleotide-gated (CNG) ion channels, binding of cGMP or cAMP drives a conformational change that leads to opening of an ion-conducting pore. One region implicated in the coupling of ligand binding to opening of the pore is the C linker region. Here, we used crosslinking of endogenous cysteines to study interregion proximity. We demonstrate that an individual amino acid--C481--in the C...

Signal transduction in neurons is a dynamic process, generally thought to be driven by transient changes in the concentration of second messengers. Here we describe a novel regulatory mechanism in which the dynamics of signaling through cyclic AMP are mediated by activity-dependent changes in the affinity of the hyperpolarization-activated, cation nonselective (HCN) channels for cAMP, rather th...