The capacity of allosensitized thymus-derived lymphocytes to destroy target cells bearing donor alloantigens is modulated by the cellular levels of cyclic AMP and cyclic GMP. Increases in the cyclic AMP levels of attacking lymphocytes by stimulation with prostaglandin E(1), isoproterenol, and cholera toxin inhibit lymphocyte-mediated cytotoxicity; whereas, depletion of cyclic AMP with imidazole...

The effect of adenosine on the increase in cardiac cyclic adenosine 3',5'-monophosphate (cyclic AMP) concentration and glycogen phosphorylase activity produced by isoproterenol was investigated. Slices of rat ventricular myocardium 0.5 mm thick weighing 15-20 mg were cut, washed, and incubated at 37 °C in physiological saline gassed with either O2 (oxygenated) or N2 (anoxia). The concentration ...

Intact rat peritoneal macrophages (rPM) treated with 3-isobutyl-1-methylxanthine (IBMX), an inhibitor of phosphodiesterases (PDEs), accumulated more cGMP than untreated cells. A PDE activity toward [(3)H]cGMP was detected in the soluble and particulate fractions of rPM. The hydrolysis of cGMP was Ca(2+)/calmodulin-independent but increased in the presence of cGMP excess. Similar results were ob...

A Z2Z4-additive code C ⊆ Z2 ×Zβ4 is called cyclic if the set of coordinates can be partitioned into two subsets, the set of Z2 and the set of Z4 coordinates, such that any cyclic shift of the coordinates of both subsets leaves the code invariant. These codes can be identified as submodules of the Z4[x]-module Z2[x]/(x− 1)×Z4[x]/(x − 1). The parameters of a Z2Z4-additive cyclic code are stated i...

To evaluate the protective effects of dexmedetomidine on colon and spinal cord rats with functional chronic visceral pain its regulatory mechanism extracellular signal-regulated kinase 1-cyclic adenosine monophosphate response element-binding protein signaling pathway. A rat model irritable bowel syndrome was established by colorectal distention stimulation. Animals were categorized into normal...

Cyclic AMP affects microvascular smooth muscle contraction and growth. Therefore, it is important to elucidate mechanisms regulating cyclic AMP production in microvascular smooth muscle. In this study, we determined whether several signal transduction pathways regulate receptor-induced cyclic AMP in isolated preglomerular microvessels and microvascular smooth muscle cells. Preglomerular microve...

Denote by G a finite group and let ? ( ) denote the sum of element orders in . In 2009, H. Amiri, S.M. Jafarian Amiri I.M. Isaacs proved that if | = n is non-cyclic, then < C , where denotes cyclic order 2018 we non-cyclic ? 7 11 equality holds 4 k with 2 1 × this paper only are as indicated above. Moreover following generalization result: Theorem Let be q being least prime divisor Then ? + 5 N...

Platelets possess alpha 2-adrenergic and serotonergic (5-hydroxytryptamine) receptors which are thought to mediate the in vitro proaggregatory effects of epinephrine and serotonin, respectively. However, their importance in platelet aggregation in vivo is uncertain. In the present study, we evaluate the ability of yohimbine and ketanserin, relatively selective alpha 2-adrenergic and serotonin a...

A binary linear code C is a Z2-double cyclic code if the set of coordinates can be partitioned into two subsets such that any cyclic shift of the coordinates of both subsets leaves invariant the code. These codes can be identified as submodules of the Z2[x]-module Z2[x]/(x r −1)×Z2[x]/(x − 1). We determine the structure of Z2-double cyclic codes giving the generator polynomials of these codes. ...