[Purpose] This study aimed to evaluate the mediating effect of gross motor function, measured using the Gross Motor Function Measure (GMFM) and of general function, measured using the International Classification of Functioning, Disability and Health-Child and Youth Check List (ICF-CY), on the ICF domains of activity and participation in children with cerebral palsy (CP). [Subjects] Ninety-five...

In this paper we study two different topics. The first topic is the applications of the geometric quantization scheme of Witten introduced in [2] and [16] to the problem of the quantum background independence in string theory. The second topic is the introduction of a Z structure on the tangent space of the moduli space of polarized CY threefolds M(M). Based on the existence of a Z structure on...

Relationship between depression of early protection against influenza virus infection and the decrease in the number of peripheral polymorphonuclear leukocytes (PMN) in cyclophosphamide (CY)-treated mice was investigated using d-Lenolate (Lenolate), which had been shown to exert a potent restorative effect on leukocytopenia in immuno-compromised hosts. Following intranasal inoculation with infl...

Cyclophosphamide (CY)-mediated immunoenhancement has been attributed to the inhibition of suppressor T-cell generation. In order to exert its effects on the immune system, metabolic activation of CY is required. The metabolite of CY responsible for its immunoenhancing properties are not known. Two reactive metabolites of CY which may inhibit suppressor T-cell generation are phosphoramide mustar...

Since increasing evidence indicates that combination modality of cancer treatment is preferable, and a series of 5-halo-6-phenyl pyrimidinones has been found to induce interferon production and to stimulate a variety of immune responses, several were tested alone or in combination with cyclophosphamide (CY) against B16 melanoma and P388 leukemia. Thus far, 2-amino5-bromo-6-(3-fluorophenyl)-4(3H...

OBJECTIVES The purpose of our study was to assess the chondrogenic potential and the MR signal effects of GadofluorineM-Cy labeled matrix associated stem cell implants (MASI) in pig knee specimen. MATERIALS AND METHODS Human mesenchymal stem cells (hMSCs) were labeled with the micelle-based contrast agent GadofluorineM-Cy. Ferucarbotran-labeled hMSCs, non-labeled hMSCs and scaffold only serve...

The antitumor immune response activated by IL-12, especially by a combination of cyclophosphamide and IL-12 (Cy+IL-12), is clinically significant in certain experimental tumor models, in that a number of well-established (10-20 mm in diameter) s.c. tumors are completely eradicated. Furthermore, Cy+IL-12 treatment is also able to eradicate well-established grossly detectable experimental lung me...

Cytokine-mobilized peripheral blood hematopoietic stem cells (MPB HSC) are widely used for transplantation in the treatment of malignancies, but the mechanism of HSC mobilization is unclear. Although many HSC in bone marrow (BM) cycle rapidly and expand their numbers in response to cytoreductive agents, such as cyclophosphamide (CY), and cytokines, such as granulocyte colony-stimulating factor ...

CYCLOSPORINE (Cy A)-induced pseudo-graft-versus-host disease (GVHD) developing in syngeneic rat bone marrow chimeras has features resembling classical acute and later chronic GVHD in the fully allogeneic bone marrow chimera. 1 These features develop in the early post-CyA period, and usually result in a mild, acute form of GVHD, followed by a more chronic autoimmunelike syndrome in a high percen...

We introduce some new algebraic structures arising naturally in the geometry of CY manifolds and mirror symmetry. We give a universal construction of CY algebras in terms of a noncommutative symplectic DG algebra resolution. In dimension 3, the resolution is determined by a noncommutative potential. Representation varieties of the CY algebra are intimately related to the set of critical points,...