Myeloid Sarcoma (MS) is a rare malignancy that can present as an isolated disease or more frequently in association with or following acute myeloid leukemia or other myeloid neoplasms and rarely following myelofibrosis. Since molecular pathogenesis and prognostic factors of MS are not well understood, its prognosis remains poor even in the era of novel agents and target therapies. We report the...

Since the advent of highly active antiretroviral therapy (HAART), the incidence of acquired immunodeficiency syndrome- (AIDS-) related Kaposi's sarcoma (KS) has decreased dramatically. While cutaneous KS is the most common and well-known manifestation, knowledge of alternative sites such as the gastrointestinal (GI) tract is important. GI-KS is particularly dangerous because of its potential fo...

A case of aneurysmal ("angiomatoid") fibrous histiocytoma (AFH) in a 12-year-old girl is presented with its unusual clinicopathologic features. The lesion had the full microscopic characteristics of AFH described in prior reports, but it also had some features that differed from the original description of the disorder, such as the involvement of subcutis, its occurrence in the scalp, and a doc...

BACKGROUND Since the advent of the HIV/AIDS pandemic, Kaposi's sarcoma (KS) is now seen in places not previously considered endemic for this disease. In Nigeria, the African-endemic KS had been known to be prevalent in the southern parts of the country, particularly the southeast. Until now, reports on the disease from northern Nigeria are few. OBJECTIVE To describe the prevalence ofKaposi's ...

Histone deacetylases (HDAC) are key players in epigenetic regulation of gene expression and HDAC inhibitor (HDACi) treatment seems to be a promising anticancer therapy in many human tumours, including soft tissue sarcomas. HR23b has been shown to be a potential biomarker for sensitivity to HDACi therapy in cutaneous T-cell lymphoma and hepatocellular carcinoma. We aimed to evaluate HR23b as a c...

BACKGROUND In this study, the clinical and morphological features of vesiculobullous lesions observed in Kaposi sarcoma are analyzed, and the features of bullous Kaposi sarcoma cases are emphasized. METHODS A total of 178 biopsy materials of 75 cases diagnosed as classic-type cutaneous Kaposi sarcoma were reviewed. Twenty-five cases showing vesiculobullous features were included in the study....

AFX: atypical fibroxanthoma BCC: basal cell carcinoma PDS: pleomorphic dermal sarcoma SCC: squamous cell carcinoma INTRODUCTION Atypical fibroxanthoma (AFX) is a neoplastic skin disease that arises from myofibroblasts and most commonly occurs in elderly patients on sun-exposed skin. Immunohistochemistry is commonly used to make the diagnosis of AFX. Findings are positive for vimentin, CD10e, CD...

background: bone sarcomas are the most common malignancies of bone tissues in children, and are classified intotwo groups as osteosarcoma and ewing’s sarcoma. treatment and prognosis depend on the subtype and grade ofthe tumor. the goal of this study was to evaluate the features bone sarcoma in patients referred to mahak childrenhospital since 2007 to 2009.materials and methods: this was a retr...

although rare, synovial sarcoma is the most common malignant non-rhabdomyosarcomatous soft tissue sarcoma in children and adolescents. synovial sarcoma typically involves the soft tissues of the extremities, especially near large joints, but it can occur anywhere in the body in locations far from joint spaces. although this tumor typically affects adults in their fourth decade of life, nearly h...

we report a 75 year - old man who presented with a cervical mass, dysphagia anil hoarseness, ct - xcan of neck showed a large cold nodule in the right lobe of thyroid gland, which was followed by surgical excision and its histopathologic exam revealed well-differentiated chondrosarcoma.