The issue as to whether oral lichen planus is a premalignant disorder is still controversial. This study aimed to examine oral malignancies associated with oral lichen planus and to investigate whether oral lichen planus has an intrinsic malignant potential or whether there are also contributing external risk factors. A retrospective cohort study in 200 Caucasian patients with oral lichen planu...

Lichen planus pigmentosus (LPP) is a variant of lichen planus. It characterized by small black, brown macules, on sun exposed areas like face, neck, upper extremities and trunk. Lesions are insidious in onset with gradually progressive course. Few variants have been reported LPP inversus, localized LPP, linear zosteriform oral mucosa etc. Here, we present case young adolescent male, which rare ...

BACKGROUND Topical tacrolimus has been reported to be an effective treatment for genital lichen planus in small case series. We retrospectively reviewed the medical records of 16 patients with symptomatic vulvar lichen planus who received treatment with tacrolimus ointment. OBSERVATIONS All patients had symptomatic vulvar lichen planus recalcitrant to other treatments. Of 16 patients, 15 (94%...

BACKGROUND Topical tacrolimus has been reported to be effective for the treatment of oral lichen planus. This article describes our experience with topical tacrolimus in patients treated for symptomatic oral lichen planus. OBSERVATIONS A survey was mailed to 40 patients with symptomatic oral lichen planus treated with topical tacrolimus. Surveys were completed by 37 patients (93%) a mean of 1...

BACKGROUND Oral lichen planus and mouth dryness are common pathoses, yet not entirely understood. These two conditions may be associated, with a few studies investigating the relationship between mouth dryness and oral lichen planus providing conflicting results. None of the studies have explored the specific impact of disease treatment on mouth dryness. OBJECTIVE The purpose of this observat...

STATEMENT OF THE PROBLEM Lichen planus is a mucocutaneous disease that is relatively common in middle aged individuals. Some studies have shown that oral lichen planus has a potential to progress to squamous cell carcinoma.p21 is a cyclin-dependent kinase inhibitor that regulates the cell cycle, thus it acts as an inhibitor in cell proliferation. PURPOSE This study was aimed to evaluate and c...

Aims-To determine which inflammatory and immune pathways are implicated in the development of chronic graft versus host disease (GvHD) and whether differences between these pathways are responsible for the different presentations of chronic GvHD.Methods-Biopsy specimens of diseased and normal skin were obtained from patients presenting with lichen planus-like and sclerodermatous type chronic Gv...

Introduction Oral lichen planus (OLP) is a chronic T cell mediated disease of oral mucosa, skin, and its appendages with a prevalence of 0.5 to 2.6% worldwide. Oral lichenoid reactions (OLR) are a group of lesions with diverse aetiologies but have clinical and histological features similar to OLP, thereby posing a great challenge in differentiating both lesions. Mast cells are multifunctional i...

Background: Lichen planus is a chronic inflammatory disease ofunknown etiology that may involve mucocutaneous tissues. Themain aim of our study was to evaluate the frequency of oral andgenital lichen planus in men and women affected by skin lesions.Method: A total of 132 patients with clinical and histopathologicaldiagnosis of lichen planus were evaluated for oral and genitalinvolvement. All da...