The genus Acanthamoeba includes species of free-living soil and water ameba that have been implicated in a small number of human diseases. Acanthamoeba species have been identified as the etiologic agents in 2 well-defined clinical entities, amebic keratitis and granulomatous amebic encephalitis (GAE). Less commonly, Acanthamoeba species have been identified as the cause of disseminated disease...

Cutaneous T-cell lymphoma (CTCL) are a heterogeneous group of neoplasms of skin-homing T cells that show considerable variation in clinical presentation, histological appearance, immunophenotype and prognosis. In recent classification schemes (WHO-EORTC; WHO 2008) roughly three categories of CTCL can be distinguished: (1) the group of classical CTCL, including mycosis fungoides (MF, variants or...

The "traumatic degeneration" of peripheral nerves has been described by Ram6n y Cajal (16) as representing the alteration of both myelin sheath and axon in the central stump of a damaged nerve, in contrast to Wallerian degeneration in the distal part of the same nerve. Distal nerve degeneration and subsequent regeneration after mechanical injuries of peripheral nerve bundles have been well-docu...

Granuloma faciale (GF) is a rare, inflammatory, cutaneous disorder of unknown aetiology. It presents clinically as one or several well-circumscribed violaceous papules, plaques, and nodules almost exclusively confined to the facial region. Rarely, extrafacial lesions can occur, most often on sun-exposed sites. We report a case of extrafacial GF in a 63-year-old male with indolent lymphoma, who ...

Acanthamoeba are abundant in a wide range of environments, and some species are responsible for cutaneous infections, keratitis, and granulomatous amoebic encephalitis (GAE). The conventional detection and isolation of amoeba from clinical and environmental samples involves sampling and culture on non-nutrient Ágar medium. Although efficient, this system requires several transfers in order to e...

Rare molds are increasingly emerging as a cause of deep and invasive fungal infections. We report here a rare case of cutaneous phaeohyphomycosis of the lower limbs due to Alternaria alternata associated with extra-ungual localization of Scopulariopsis brevicaulis. Diagnosis was made based on repeated, direct, microscopic mycological and histological examinations. The study revealed hyphae and ...

Figures 2a-2c: Superficial and deep, perivascular and interstitial infiltrate of lymphocytes, histiocytes, numerous eosinophils and neutrophils, with a foci of basophilic collagen degeneration surrounded by numerous eosinophils. (2b, 2c: Higher-power views.) Abstract Palisaded neutrophilic and granulomatous dermatitis (PNGD) is thought to be an uncommon cutaneous manifestation associated with r...

Seven months after undergoing kidney transplantation, a 56-year-old woman presented with papules and ulcers in her right forearm. The patient received antibiotics for 8 months with limited improvement. Eleven months after symptom onset, she presented with acute arthritis in her left knee. Asynovial fluid culture yielded Mycobacterium tuberculosis, and a forearm ulcer biopsy showed granulomatous...

We present a rare disease condition Hermansky-Pudlak syndrome in a 33-year-old male. He was born of a consanguineous marriage, had occulo-cutaneous albinism, nystagmus, decreased visual acuity, refractory errors, pulmonary fibrosis and granulomatous inflammation of the colon. In spite of all the classical features of this genetic disorder he was labeled to have disseminated tuberculous infectio...

Mycobacterium marinum, the cause of chronic systemic infections in fish, occasionally causes granulomatous skin and soft tissue lesions in humans. Cutaneous mycobacterial infection in two patients owing to unusual circumstances is presented in this report. The first patient was infected through improper hygienic behavior, while infection in the second patient was previously misdiagnosed as rheu...