414 http://e-aair.org I recently read the article Threshold for Positivity and Optimal Dipyrone Concentration in Flow Cytometry-Assisted Basophil Activation Test by Hagau et al., in the August 2013 issue of AAIR, where the authors assessed the usefulness of basophil activation tests (BATs) in the diagnosis of allergy to dipyrone. Allergy to dipyrone still represents a main concern and pyrazolon...

The wide variety of Leishmania species responsible for human American cutaneous leishmaniasis combined with the immune mechanisms of the host results in a large spectrum of clinical, histopathological, and immunopathological manifestations. At the middle of this spectrum are the most frequent cases of localized cutaneous leishmaniasis (LCL) caused by members of the subgenera Leishmania and Vian...

BACKGROUND Immediate-type hypersensitivity to animal proteins is a common problem in people occupationally exposed to animals. METHODS A 19-year-old female working as a voluntary zookeeper in her off-time suffered from hives on her forearms following contact to the fur of a giraffe. For diagnostic evaluation, skin prick tests, assessment of specific serum IgE antibodies, and basophil activati...

Alcohol sensitivity is reported in up to 74-86.5% of patients with chronic rhinosinusitis nasal polyposis (CRSwNP) and especially those aspirin-exacerbated respiratory disease (AERD). These typically report beverages fermented wood casks, fruit skins, or hops, but not other alcohol-containing drinks. We speculated that alcohol AERD/CRSwNP could result from activation basophils by polyphenols de...

PURPOSE OF REVIEW The present review addresses the most recent literature regarding the diagnosis of drug hypersensitivity reactions, which can be classified as immediate or nonimmediate according to the time interval between the last drug administration and the onset. Immediate reactions occur within 1 h; nonimmediate ones occur after more than 1 h. RECENT FINDINGS Clinical and immunological...

INTRODUCTION There are rather few publications about hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAID) in the paediatric age. In this study, we aimed to assess the frequency of confirmed NSAID hypersensitivity in children with a previous reported reaction to NSAID in order to investigate the role of the drug provocation test (DPT) in the diagnostic workup and to explor...

Clinical & Experimental AllergyVolume 51, Issue 7 p. 980-981 CORRESPONDENCE Basophil activation test in the diagnosis of hypersensitivity reactions to quinolones by Loli-Ausejo et al Didier G. Ebo, Corresponding Author [email protected] orcid.org/0000-0003-0672-7529 Faculty Medicine and Health Sciences, Department Immunology, Allergology, Rheumatology Infla-Med Centre Excellence, University ...

In chronic spontaneous urticaria (CSU), a decrease in the number of basophils peripheral blood (PB), or basopenia, is observed. However, its mechanism has not been clarified. Therefore, we examined whether basopenia CSU reflects infiltration inflamed skin. First, compared basophil counts PB before and after treatment. The increased following improvement symptom 15 out 17 patients treated with o...