Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and is triggered via abnormal accumulation of amyloid-β peptide (Aβ). Aggregated Aβ is responsible for disrupting calcium homeostasis, inducing neuroinflammation, and promoting neurodegeneration. In this study, we generated curcuminoid submicron particle (CSP), which reduce the average size to ~60 nm in diameter. CSP had ...

A novel method for analysis of three active components curcumin, demethoxycurcumin and bisdemethoxycurcumin in Curcuma longa L. was developed by HPLC coupled with electrochemical detection. Three curcuminoids were well separated on a C18 column and detected with high sensitivity. A mobile phase containing acetonitrile and 10 mM Na2HPO4-H3PO4 (pH 5.0) (50:50, v/v) was used. Good linearity was ob...

Curcumin, the active molecule present in Curcuma longa is known for its antitumour, antioxidant, antiarthritic, anti-amyloid, anti-ischemic, anti-inflammatory activities. In addition, it may also be effective in treating malaria, prevention of cervical cancer, etc. High-performance thin-layer chromatography (HPTLC) method has been employed for determination of curcumin in four varieties of turm...

Turmeric (Curcuma longa L.) is an economically important spice and medicinal plant for production of curcuminoids, oleoresin, essential oil which are used in pharmaceutical and cosmetics industries. Presence of these contents in turmeric determine its quality. Average productivity and quality of turmeric is not satisfactory because of the poor genetic materials and non-availability of quality m...

The sesquiterpenoids are one of major groups of antioxidants in Curcuma besides curcuminoids. However, the real substances contributing to the antioxidant activity are still unknown. In this paper, the antioxidant activity of sesquiterpenoids in four species and two essential oils from Curcuma genus was determined and compared based on TLC separation and DPPH bioautography assay. Their antioxid...

Abstract In current years, natural pigments are facing a fast-growing global market due to the increase of people’s awareness health and discovery novel pharmacological effects various pigments, e.g., carotenoids, flavonoids, curcuminoids. However, traditional production approaches source-dependent generally subject low contents target pigment compounds. order scale-up industrial production, ma...