BACKGROUND Stroke management would benefit from a broadly available imaging tool that detects perfusion deficits in patients with acute stroke. OBJECTIVE To determine the role of dynamic, single-slice computed tomographic (CT) perfusion imaging (CTP) in the assessment of acute middle cerebral artery stroke. DESIGN AND PATIENTS Imaging with CTP and CT within the first 6 hours of symptom onse...

BACKGROUND AND PURPOSE Different imaging paradigms have been used to select patients for endovascular therapy in stroke. We sought to determine whether computed tomographic perfusion (CTP) selection improves endovascular therapy outcomes compared with noncontrast computed tomography alone. METHODS Review of a prospectively collected registry of anterior circulation stroke patients undergoing ...

9-beta-D-Arabinofuranosyladenine (ara-A), 1-beta-D-arabinofuranosylcytosine (ara-C), and their 5'-triphosphates (ara-ATP and ara-CTP) were tested for ability to inhibit the hepatitis B virus (HBV)-associated deoxyribonucleic acid (DNA) polymerase. Ara-C did not inhibit the HBV DNA polymerase at the concentrations tested, ara-A did so by 50% at a concentration of 30 mM, with the inhibition nonco...

The Child-Turcotte-Pugh (CTP) score is widely used worldwide to predict outcomes across a broad spectrum of liver diseases, mainly cirrhosis. Portal hypertension and variceal bleed are significant causes of morbidity and mortality in cirrhotic patients, although the variceal status is not incorporated into the classical CTP score. We sought to determine whether the inclusion of variceal status,...

The discovery of large supramolecular complexes such as the purinosome suggests that subcellular organization is central to enzyme regulation. A screen of the yeast GFP strain collection to identify proteins that assemble into visible structures identified four novel filament systems comprised of glutamate synthase, guanosine diphosphate-mannose pyrophosphorylase, cytidine triphosphate (CTP) sy...

Objective: Flat detector CT perfusion (FD-CTP) imaging is a new modality that permits rapid assessment of the state of perfusion in the angiography suite. We present a case in which FD-CTP was useful for the determination of the therapeutic strategy for embolism that occurred during angiography. Case Presentation: Cerebral angiography performed before surgery for brain tumor suggested left post...

Arabinosylcytosine (ara-C) is a cytotoxic agent with major activity against acute leukemias. To exert this effect, it must first be phosphorylated to its active 5'-triphosphate, ara-CTP, which is incorporated into DNA. Our previous studies demonstrated that preincubation with arabinosyl-2-fluoroadenine (F-ara-A) increased the rate of ara-CTP accumulation in leukemia cells when incubated with 10...

A reinvestigation of a Fijian collection of Cacospongia mycofijiensis has yielded the known mycothiazole and a novel heterocyclic, CTP-431 (1). Its structure including absolute configuration as 8R,9R,10S,13S was established using NMR data, calculated DFT (13)C chemical shifts and results from X-ray crystallography. It is possible that the tricyclic skeleton of CTP-431 (1) is biosynthetically re...

Given an undirected graph G = (V ∪W,E), where V ∪W is the vertex set and E is the edge set, the COVERING TOUR PROBLEM (CTP) consists of determining a minimum length cycle over a subset of V which contains all vertices of T ⊆ V , and every vertex of W is covered by the tour. This work presents a new integer linear programming formulation, a new reduction rule and new heuristic algorithms for the...

Abstract Funding Acknowledgements Type of funding sources: None. Background Non-invasive techniques have evolved as "gatekeepers" to invasive coronary angiography (ICA) for symptomatic patients with suspected or known artery disease (CAD). Evaluation myocardial ischemia functional tests represents a milestone in CAD detection proved diagnostic and prognostic power. Coronary computed tomography ...