Cobalt(II) complexes with the non-steroidal anti-inflammatory drug mefenamic acid in the presence or absence of nitrogen donor heterocyclic ligands (2,2'-bipyridine, 1,10-phenanthroline or pyridine) have been synthesized and characterized with physicochemical and spectroscopic techniques. The experimental data suggest that mefenamic acid acts as deprotonated monodentate ligand coordinated to Co...

A homology search of wheat chloroplast (ct) and mitochondrial (mt) genomes identified 54 ctDNA segments that have homology with 66 mtDNA segments. The mtDNA segments were classified according to their origin: orthologs (prokaryotic origin), xenologs (interorganellar DNA transfer origin) and paralogs (intraorganellar DNA amplification origin). The 66 mtDNA sequences with homology to ctDNA segmen...

Carney triad (CT) is a rare condition with synchronous or metachronous occurrence of gastrointestinal stromal tumors (GISTs), paragangliomas (PGLs), and pulmonary chondromas in a patient. In contrast to Carney-Stratakis syndrome (CSS) and familial PGL syndromes, no germline or somatic mutations in the succinate dehydrogenase (SDH) complex subunits A, B, C, or D have been found in most tumors an...

CTP:phosphocholine cytidylyltransferase (CT) catalyzes a rate limiting reaction in the synthesis of phosphatidylcholine in higher eucaryotes. CT is subject to regulation by interconversion between an inactive cytosolic form and an active membrane bound form. This translocation is controlled by lipid activators and phosphorylation. At present, only the sequence of the rat liver CT cDNA and the y...

A series of bis-naphthalimide derivatives with different diamine linkers were designed and synthesized. All of the synthesized bis-naphthalimide derivatives were characterized by NMR and HRMS spectra. The binding ability between the compounds and CT DNA was evaluated by using UV-Vis titration experiments. The bis-naphthalimide compound with an ethylenediamine linker showed the largest binding c...

The direct interaction of hairpin DNA with 9-hydroxyfluorene (9-OHFLU) through hydrogen bonds was investigated by electrochemical impedance spectroscopy (EIS), UV-Vis spectroscopy and (1)H NMR spectra. Based on these results, an electrochemical hairpin DNA sensor was developed for the detection of 9-OHFLU by EIS. Upon 9-OHFLU interacting with hairpin DNA film on the gold electrodes, the charge ...

A Charge Transport (CT) mechanism has been proposed in several papers (e.g., Yavin et al. PNAS 102 3546 (2005)) to explain the localization of Base Excision Repair (BER) enzymes to lesions on DNA. The CT mechanism relies on redox reactions of iron-sulfur cofactors that modify the enzyme’s binding affinity. These redox reactions are mediated by the DNA strand and involve the exchange of electron...

organisms. Analytical sensitivity was determined using titered, purified CT elementary bodies and cultured NG cells. Results The Xpert CT/NG assay detects all CT serovars, new variant CT, and 48 geographically diverse NG strains. The CT primers and probes do not cross-react with DNA or RNA from non-trachomal species. All non-gonococcal Neisseria species yielded negative results, including N. mu...

Damaged or mismatched bases in DNA can be repaired by base excision repair enzymes (BER) that replace the defective base. Although the detailed molecular structures of many BER enzymes are known, how they colocalize to lesions remains unclear. One hypothesis involves charge transport (CT) along DNA [Yavin et al., Proc. Natl. Acad. Sci. U.S.A. 102, 3546 (2005)]. In this CT mechanism, electrons a...

Limited understanding of ovarian cancer (OC) genome portrait has hindered the therapeutic advances. The serial monitoring of tumor genotypes is becoming increasingly attainable with circulating cell-free DNA (cf-DNA) and circulating tumor cells (CTCs) emerging as "liquid biopsies". They represent non-invasive biomarkers and are viable, as they can be isolated from human plasma, serum and other ...