Animals perceiving repeated aversive events can become chronically stressed. Chronic activation of the hypothalamic-pituitary-adrenal (HPA) axis can have deleterious consequences on physiological parameters (e.g. BW, blood chemistry) and behaviour (e.g. emotional reactivity, stereotypies, cognition). Environmental enrichment (EE) can be a mean to reduce animal stress and to improve welfare. The...

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and is triggered via abnormal accumulation of amyloid-β peptide (Aβ). Aggregated Aβ is responsible for disrupting calcium homeostasis, inducing neuroinflammation, and promoting neurodegeneration. In this study, we generated curcuminoid submicron particle (CSP), which reduce the average size to ~60 nm in diameter. CSP had ...

When we want to use brain-computer interfaces (BCI) as an input modality for gaming, a short setup procedure is necessary. Therefore a user model has to be learned using small training sets. The common spatial patterns (CSP) algorithm is often used in BCI. In this work we investigate how the CSP algorithm generalizes when using small training sets, how the performance changes over time, and how...

Cisplatin (CSP) is a chemotherapeutic agent commonly used to treat a variety of malignancies. The major setback with CSP treatment is that its clinical efficacy is compromised by its induction of organ toxicity, particular to the kidneys and ears. Despite the significant strides that have been made in understanding the mechanisms underlying CSP-induced renal toxicity, advances in developing ren...

The process algebra Csp [1] [4] [15] [16] is a formal method devoted to the modelling as well as to the analysis and verification of concurrent systems. It is a speciality of Csp that it captures both, the concurrent system as well as its desired properties, as specifications: Let Sys be the formal Csp model of a concurrent system, let P be a property formulated in Csp – such a property could, ...

The existing testing theories for CSP cater verification of interaction patterns (traces) and deadlocks, but not time. We address here refinement based on a dialect CSP, called tock -CSP, which can capture discrete time properties. This version has been widespread interest decades; recently, it given denotational semantics, model checking become possible using well established tool. Here, we fi...

Previous studies suggest that the vesicular cysteine-string protein (CSP) may modulate presynaptic Ca(2+) channel activity in fast neurotransmitter release. To test this hypothesis, we analyzed the dynamics of presynaptic Ca(2+) ion influx with the Ca(2+) indicator fluo-4 AM at csp mutant neuromuscular junctions of Drosophila. From 24 to 30 degrees C, stimulus-evoked, relative presynaptic Ca(2+...

Caspases are cysteine proteases that can drive apoptosis in metazoans and have critical functions in the elimination of cells during development, the maintenance of tissue homeostasis, and responses to cellular damage. Although a growing body of research suggests that programmed cell death can occur in the absence of caspases, mammalian studies of caspase-independent apoptosis are confounded by...

Cold shock-domain family proteins (Csps) are highly conserved nucleic acid binding proteins regulating the expression of various genes including those involved in stress resistance and virulence in bacteria. We show here that Csps are involved in virulence, cell aggregation and flagella-based extracellular motility of Listeria monocytogenes. A L. monocytogenes mutant deleted in all three csp ge...