OBJECTIVE Despite the advent and expanding access to antiretroviral therapy, HIV-associated cryptococcal meningitis (CM) remains a significant cause of mortality and morbidity amongst individuals with this infection in resource-limited settings. METHODS We prospectively studied the clinical, biochemical and mycological parameters of 30 HIV patients diagnosed with cryptococcal meningitis at ou...

It is estimated that fungal infections cause 1 million deaths annually, accounting for 50% of all AIDS-related deaths [1]. In this specific patient group, data from 2009 revealed that fungal meningitis is responsible for approximately 500,000 deaths each year [2]. The most common fungal pathogen infecting the brain is Cryptococcus neoformans, a yeastlike pathogen that is highly efficient in cau...

Introduction: Cryptococcal meningitis is a rare disorder that is caused by Cryptococcus neoformans in immunocompromised host. CasePresentation: The case was a 64-year-old man with a history of stem cell transplant for acute leukemia, who presented chronic meningitis caused by Cryptococcus neoformans and concurrent neoplastic meningitis with presence of malignant cells only in his cerebrospinal ...

Table. Registration status, availability and price of flucytosine and amphotericin B in 9 African countries.

To determine patient characteristics associated with isoniazid resistance in cases of tuberculous meningitis, we conducted a cross-sectional study by using data from the US National Tuberculosis Surveillance System during 1993-2005. Foreign-born patients were more likely to be infected with an isoniazid-resistant strain.

TO THE EDITOR—Jarvis et al describe the evaluation of a point-of-care antigen test for cryptococcal meningitis against a quantitative sandwich enzyme-linked immunosorbent assay using the Spear-man rank correlation coefficient [1].

Although cryptococcal meningitis is uncommon in children and rare in neonates, it does occur. We highlight circumstances in which the diagnosis should be considered and methods required to confirm the diagnosis in young patients.

Chorioretinitis occurred in a young man whose long-standing cryptococcal meningitis had been identified and treated. In one eye spontaneous resolution had occurred. His case history and fluorescein angiograms are presented.

We reported a cryptococcal meningitis Aids-patient infected with a mating type VNI isolate showing filamentous cells in direct examination of cerebrospinal fluid. Clinical data, outcome, treatment features and microbiological findings were discussed.