نتایج جستجو برای: cryptic rearrangement

تعداد نتایج: 36963  

Journal: :Journal of microbiology and biotechnology 2017
Dongbin Park Yoonsoo Hahn

A distinct double-stranded RNA (dsRNA) cryptic virus, named spinach cryptic virus 1 (SpCV1), was identified from spinach transcriptome datasets. The SpCV1 genome has two dsRNA genome segments. The larger dsRNA1 has an open reading frame for a conserved RNA-dependent RNA polymerase (RdRp). The smaller dsRNA2 encodes a putative coat protein (CP). The sequence identity of SpCV1 RdRp and CP to the ...

2018
Seth C Britch Kenneth J Linthicum Robert L Aldridge Mark S Breidenbaugh Mark D Latham Peter H Connelly Mattie J E Rush Jennifer L Remmers Jerry D Kerce Charles A Silcox

We conducted aerial fixed wing ultra low volume (ULV) spray trials with naled to investigate penetration of exposed and simulated cryptic habitat within opened buildings, partially sealed buildings, and outdoor locations targeting sentinel adult Aedes aegypti mosquitoes in north central Florida. Mortality was observed in open and closed buildings and outdoors, even in mosquitoes placed in crypt...

In this paper, a novel method for loss reduction and efficiency optimization of the high frequency flyback transformers is proposed based on rearrangement of the windings. According to detailed analysis of the high frequency flyback transformer using FEM technique, a novel and simple approach for its design improvement and loss reduction is introduced. It is shown that leakage flux scattering i...

Journal: :The Journal of biological chemistry 2006
Negar S Rahman LeAnn J Godderz Stephen J Stray J Donald Capra Karla K Rodgers

Antibody and T cell receptor genes are assembled from gene segments by V(D)J recombination to produce an almost infinitely diverse repertoire of antigen specificities. Recombination is initiated by cleavage of conserved recombination signal sequences (RSS) by RAG1 and RAG2 during lymphocyte development. Recent evidence demonstrates that recombination can occur at noncanonical RSS sites within I...

2016
Xiaowen Liang Brandon L. Garcia Livia Visai Sabitha Prabhakaran Nicola A. G. Meenan Jennifer R. Potts Martin J. Humphries Magnus Höök

Adherence of microbes to host tissues is a hallmark of infectious disease and is often mediated by a class of adhesins termed MSCRAMMs (Microbial Surface Components Recognizing Adhesive Matrix Molecules). Numerous pathogens express MSCRAMMs that specifically bind the heterodimeric human glycoprotein fibronectin (Fn). In addition to roles in adhesion, Fn-binding MSCRAMMs exploit physiological Fn...

Journal: :EMBO reports 2013
Herbert B Schiller Reinhard Fässler

Cells perceive information about the biochemical and biophysical properties of their tissue microenvironment through integrin-mediated cell-matrix adhesions, which connect the cytoskeleton with the extracellular matrix and thereby allow cohesion and long-range mechanical connections within tissues. The formation of cell-matrix adhesions and integrin signalling involves the dynamic recruitment a...

2014
Danielle M. Townsley Bogdan Dumitriu Neal S. Young

Our understanding of the pathophysiology of aplastic anemia is undergoing significant revision, with implications for diagnosis and treatment. Constitutional and acquired disease is poorly delineated, as lesions in some genetic pathways cause stereotypical childhood syndromes and also act as risk factors for clinical manifestations in adult life. Telomere diseases are a prominent example of thi...

Journal: :The Biochemical journal 2012
Márcia A Liz Sérgio C Leite Luiz Juliano Maria J Saraiva Ana M Damas Daniel Bur Mónica M Sousa

TTR (transthyretin) was found recently to possess proteolytic competency besides its well-known transport capabilities. It was described as a cryptic serine peptidase cleaving multiple natural substrates (including β-amyloid and apolipoprotein A-I) involved in diseases such as Alzheimer's disease and atherosclerosis. In the present study, we aimed to elucidate the catalytic machinery of TTR. Al...

2007
Abebe Akalu Jennifer M. Roth Maresa Caunt Desiree Policarpio Leonard Liebes Peter C. Brooks

Angiogenesis and tumor metastasis depend on extracellular matrix (ECM) remodeling and subsequent cellular interactions with these modified proteins. An in-depth understanding of how both endothelial and tumor cells use matriximmobilized cryptic ECM epitopes to regulate invasive cell behavior may lead to the development of novel strategies for the treatment of human tumors. However, little is kn...

Journal: :Zootaxa 2016
Vinh Quang Luu Michael Bonkowski Truong Quang Nguyen Minh Duc Le Nicole Schneider Hanh Thi Ngo Thomas Ziegler

Species designated as 'cryptic' share a similar morphotype, and are often only clearly separable by molecular data. Cyrtodactylus, the most diverse gecko genus of the family Gekkonidae, is a prime example, because many morphologically similar taxa have only recently been identified as new species as a result of available genetic evidence. However, while cryptic diversity of Cyrtodactylus is alr...

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