PURPOSE To identify the distribution of creatine transporter (CRT) in the aged human retina and how this expression pattern is modified after retinal detachment. METHODS An affinity-purified antibody raised against the CRT was used in the immunohistochemical investigation. The anti-CRT antibody was colocalized with neuronal markers (calbindin, parvalbumin, Islet-1, calretinin, GAD₆₇, Go-alpha...

Radiotherapy is the primary and most important adjuvant therapy for malignant gliomas. Although the mechanism of radiation resistance in gliomas has been studied for decades, it is still not clear how the resistance is related with functions of molecular chaperones in the endoplasmic reticulum. Calreticulin (CRT) is a Ca(2+)-binding molecular chaperone in the endoplasmic reticulum. Recently, it...

The CRT is an increasingly well-known and used test of bias susceptibility. While alternatives are being developed, the original remains in widespread use and this has led to its becoming increasingly familiar to psychology students (Stieger & Reips, 2016), resulting in inflated scores. Extending this work, we measure the effect of prior exposure to the CRT in a sample of oil industry professio...

Cardiac resynchronization therapy (CRT) is a relatively new therapy for patients with symptomatic heart failure resulting from systolic dysfunction. CRT is achieved by simultaneously pacing both the left and right ventricles. Biventricular pacing resynchronizes the timing of global left ventricular depolarization and improves mechanical contractility and mitral regurgitation. Published clinical...

C ardiac resynchronisation therapy (CRT) has recently been introduced to treat patients with drug refractory heart failure. 2 Studies have demonstrated immediate haemodynamic improvement after CRT, followed by improvement in symptoms, quality of life, and exercise capacity. 2 Although the majority of patients respond well to CRT, in 20% of patients symptoms do not improve. The main problem is t...

PURPOSE To compare the impact of postoperative chemoradiotherapy (CRT) versus adjuvant chemotherapy alone on recurrence and survival in patients with stage II and III upper rectal cancer undergoing curative resection. MATERIALS AND METHODS From our institutional database, 190 patients who underwent primary curative resection between 2003 and 2010 for stage II or III upper rectal cancer were i...

BACKGROUND We have previously reported strain dyssynchrony index assessed by two-dimensional speckle tracking strain, and a marker of both dyssynchrony and residual myocardial contractility, can predict response to cardiac resynchronization therapy (CRT). A newly developed three-dimensional (3-D) speckle tracking system can quantify endocardial area change ratio (area strain), which coupled wit...

In the current issue of Circulation, Anand and colleagues representing the COMPANION (The Comparison of Medical Therapy, Pacing and Defibrillation in Heart Failure) Investigators have brought forward compelling data that emphasize the substantial morbidity benefit of cardiac resynchronization therapy (CRT) in patients with moderately severe to severe heart failure. Unlike other studies that hav...

AIMS Increased sympathetic and decreased parasympathetic activity contribute to heart failure (HF) symptoms and disease progression. Carotid baroreceptor stimulation (baroreflex activation therapy, BAT) results in centrally mediated reduction of sympathetic and increase in parasympathetic activity. Because patients treated with cardiac resynchronization therapy (CRT) may have less sympathetic/p...

OBJECTIVE To assess the efficacy of prophylactic swallowing exercises on swallowing function in patients undergoing chemoradiation therapy (CRT) for head and neck cancer. DESIGN Randomized controlled trial. SETTING Tertiary care, academic medical center. PATIENTS Twenty-six patients with head and neck cancer receiving CRT. INTERVENTION Patients performed 5 targeted swallowing exercises ...