ABSTRACT Crosslinked colloidal monolayers are promising as templates, lithographic masks, filtration membranes, or membranes for controlled release rates in drug delivery. We demonstrate assembly of monodisperse micron-sized polystyrene (PS) beads at an air/water interface, which are transformed into crystalline monolayers using addition of surface-active agents. Vapor annealing methods with so...

Axons are living systems that display highly dynamic changes in stiffness, viscosity, and internal stress. However, the mechanistic origin of these phenomenological properties remains elusive. Here we establish a computational mechanics model that interprets cellular-level characteristics as emergent properties from molecular-level events. We create an axon model of discrete microtubules, which...

The wet strength of handsheets subjected to dipping treatment by solutions such as glyoxal with Zn(NO3)2 as a catalyst, chitosan, and the crosslinking system of glyoxal and chitosan is studied in this paper. The crosslinking system achieved better wet strength performance than glyoxal or chitosan alone and slightly better than the sum of glyoxal and chitosan in the case of a curing temperature ...

In this study, dimmer-acid-based hybrid nonisocyanate polyurethanes (HNIPUs) were synthesized by the one-step method without catalyst. Three polyamines and two epoxy resins were selected as raw materials for HNIPU, and cyclic carbonate was synthesized based on our previous work. All of the products were characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calor...

Wild-type and variant forms of transthyretin (TTR), a normal plasma protein, are amyloidogenic and can be deposited in the tissues as amyloid fibrils causing acquired and hereditary systemic TTR amyloidosis, a debilitating and usually fatal disease. Reduction in the abundance of amyloid fibril precursor proteins arrests amyloid deposition and halts disease progression in all forms of amyloidosi...

production and characterization of soft cross-linked gelatin sponge by using glutaraldehyde for blood hemostasis application, is the goal of this study. biodegradable hydrogels were prepared through crosslinking of gelatin with glutaraldehyde followed by freeze drying. the effects of gelatin concentration, amount of crosslink agent and freeze drying temperature on mechanical properties and elas...

RNA-protein interactions influence many biological processes. Identifying the binding sites of RNA-binding proteins (RBPs) remains one of the most fundamental and important challenges to the studies of such interactions. Capturing RNA and RBPs via chemical crosslinking allows stringent purification procedures that significantly remove the non-specific RNA and protein interactions. Two major typ...

Introduction: The cornea may become infected and perforated after epithelium-on collagen crosslinking. Case presentation: A healthy 33-year-old male who underwent corneal collagen crosslinking in both eyes developed a purulent keratitis and bilateral corneal perforations, requiring bilateral penetrating keratoplasties. He was exposed to methicillin resistant staphylococcus aureus (MRSA) by a fa...

The spatially directed 3-dimensional (3D) remodeling of synthetic materials may be useful to regionally control cell behavior. In this work, we developed a process to synthesize hyaluronic acid hydrogels using multiple modes of crosslinking applied sequentially; a primary addition reaction to introduce protease degradable peptide crosslinks, then a UV light-induced secondary radical reaction (e...

Poly(diethylaminoethyl-g-ethylene glycol) microparticles were prepared by suspension polymerization of diethylaminoethyl methacrylate, poly(ethylene glycol) monomethacrylate and the crosslinking agent tetra(ethylene glycol) dimethacrylate in silicone oil using redox initiators. Particles of different sizes, crosslinking ratios and graft molecular weights were prepared. The changes in the swelli...