BACKGROUND Beige adipocytes comprise a unique thermogenic cell type in the white adipose tissue (WAT) of rodents and humans, and play a critical role in energy homeostasis. In this scenario, recruitment of beige cells has been an important focus of interest for the development of novel therapeutic strategies to treat obesity. PPARγ activation by full agonists (thiazolidinediones, TZDs) drives t...

In the present study, liquid chromatography-mass spectrometer (LC-MS) was used to perform untargeted metabolomics analysis of white adipose tissue (WAT) and brown (BAT) in Tupaia belangeri during cold acclimation. Differences biochemical composition between WAT BAT were compared. Clarifying how two tissues respond lower temperature terms metabolomics, which elucidate metabolic process energy ho...

Previously, our laboratory reported that weight-cycled mice outlive their obese counterparts. To gain a better mechanistic understanding of these results, we evaluated cellular senescence in white adipose tissue (WAT) of lean, obese, and weight cycled mice. Our results show that at the end of a 28 day weight loss cycle cellular senescence is significantly reduced in multiple WAT depots compared...

Gesondheidsprofessioneles moet aandag gee aan die lewensbelangrike rol wat sielkundige kwessies in die oorlewing van die persoon met borskanker speel. Dit is belangrik om te onthou dat wat so hoogdrawend “ sielkundige aspekte” genoem word, op stuk van sake niks anders is as eensaamheid nie, ’n gevoel van verwerping, ’n bekommerde gees, vrees, die stryd ten opsigte van ekonomiese druk en huislik...

The Workshop on Asian Translation (WAT) is a new open evaluation campaign focusing on Asian languages. We would like to invite a broad range of participants and conduct various forms of machine translation experiments and evaluation. Collecting and sharing our knowledge will allow us to understand the essence of machine translation and the problems to be solved. We are working toward the practi...

THE STORAGE OF ENERGY AS LIPID droplets is an essential physiology process from yeast, worms, and flies to mammals (4). In lean humans, up to 90% of carbohydrate and lipid energy stores are found in white adipose tissue (WAT), providing an essential buffer for prolonged stressors, such as pregnancy or illness. However, in the past two decades, energy storage in WAT has taken on a much more pern...

BACKGROUND Widely used as a weight loss supplement, trans-10,cis-12 conjugated linoleic acid (10,12 CLA) promotes fat loss in obese mice and humans, but has also been associated with insulin resistance. OBJECTIVE We therefore sought to directly compare weight loss by 10,12 CLA versus caloric restriction (CR, 15-25%), an acceptable healthy method of weight loss, to determine how 10,12 CLA-medi...

We previously demonstrated white adipose tissue (WAT) innervation using the established WAT retrograde sympathetic nervous system (SNS)-specific transneuronal viral tract tracer pseudorabies virus (PRV152) and showed its role in the control of lipolysis. Conversely, we demonstrated WAT sensory innervation using the established anterograde sensory system (SS)-specific transneuronal viral tracer,...