Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen that causes high morbidity and mortality. Efficacy of vaccines and antivirals to treat human CCHFV infections remains limited and controversial. Research into pathology and underlying molecular mechanisms of CCHFV and other nairoviruses is limited. Significant progress has been made in our understanding of CCHFV replication ...

context crimean-congo hemorrhagic fever (cchf) is a fatal viral disease which has 30% to 80% mortality rate. in endemic areas, livestock handlers, skin processors, veterinary staff, livestock market employees, farmers, and health care staff are at risk. diagnosis is made based on clinical manifestations, epidemiologic factors, and laboratory tests. here, we reviewed the epidemiology, clinical m...

In countries from which Crimean-Congo haemorrhagic fever (CCHF) is absent, the causative virus, CCHF virus (CCHFV), is classified as a hazard group 4 agent and handled in containment level (CL)-4. In contrast, most endemic countries out of necessity have had to perform diagnostic tests under biosafety level (BSL)-2 or -3 conditions. In particular, Turkey and several of the Balkan countries have...