background bone morphogenetic protein 7 (bmp7) has been suggested to play a protective role against kidney injury in chronic kidney disease. objectives to identify the critical molecular regulators in the early stage of diabetic nephropathy, we studied the expression of bmp7 and 2 important kidney-specific markers, podocin and tamm–horsfall protein (thp). materials and methods a diabetic nephro...

paper chromatography is an analytical technique for separating and identifying mixtures of materials. it is a useful technique since it is relatively quick, and requires small quantities of the material. by emergence of nanotechnology, paper chromatography has found many applications in biology and biotechnology. in this study, we employed gold and silver nanoparticles to detect protein bands a...

neonatal purpura fulminans is a rare and life threatening disease that can be inherited or acquired in etiology. it manifests as dic and extensive subcutaneous thrombosis. the condition is often fatal unless there is prompt diagnosis, and judicious therapy. the most important causes of this condition are infections and congenital deficiency of anticoagulant proteins c and s.in the case of pc (p...

previous work by other investigators indicates a direct relation between the amount of protein in the diet and the level of urea in the blood . however, the present report shows that the type of protein , apart from its level in the ration , also has an effect on blood urea concentrations. when adult male or female rats of two strains were fed a ration in which the only source of protein was wh...

abstractintroduction: cancer is caused by genetic abnormalities, such as mutation of ontogenesis or tumor suppressor genes which alter downstream signaling pathways and protein-protein interactions. comparison of protein interactions in cancerous and normal cells can be of help in mechanisms of disease diagnoses and treatments. methods: we constructed protein interaction networks of cancerous a...

conclusions in cases of pontaneous pneumothorax, chest x ray and computerised tomographic scan have limitations. ct scan in combination with video assisted thoracoscopic surgery improves diagnostic accuracy and facilitates appropriate management of non-resolving spontaneous pneumothorax. objectives a 15 year old boy presented to the referring hospital with a right sided spontaneous pneumothorax...

alterations in the expression of micrornas (mirnas) have been proposed to play a role in the pathogenesis of acute lymphoblastic leukemia (all) and chronic lymphocytic leukemia (cll). dicer is one of the main regulators of mirna biogenesis, and deregulation of its expression has been indicated as a possible cause of mirna alterations observed in various cancers. our aim was to analyze the expre...

the bulk of our knowledge on immunosuppression in malnutrition comes from the experiments done on cell-mediated immunity. however, malnutrition-induced modifications of humoral immunity have been less understood. the objective of this study was to determine the effects of acute protein-energy malnutrition on serum levels of immunoglobulins and their subclasses in murine models. male and female ...

background: most cancer cells become resistant to anti-cancer agents. in the last few years, a new approach for targeted therapy of human cancer has been developed using immunotoxins which comprise both the cell targeting and the cell killing moieties. methods: in the present study, the recombinant shiga toxin a1 subunit fused to human granulocyte-macrophage colony stimulating factor (a1-gm-csf...

background: serological assay based on dense granular (gra) proteins of toxoplasma gondii (t. gondii) is actually the most popular laboratory diagnostic tool to detection of toxoplasmosis. we aimed to construct a recombinant gra7-ptz57rt plasmid vectors that it is suitable for sub-cloning and gra7 protein production. m aterials and methods: souris mice were used for maintaining of t. gondii tac...